Aliphatic and alicyclic camphor imines as effective inhibitors of influenza virus H1N1 Full article
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European Journal of Medicinal Chemistry
ISSN: 0223-5234 , E-ISSN: 1768-3254 |
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| Output data | Year: 2017, Volume: 127, Pages: 661-670 Pages count : 10 DOI: 10.1016/j.ejmech.2016.10.035 | ||||||
| Tags | Influenza; Camphor derivatives; Antiviral; Cage compounds | ||||||
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Abstract:
A series of camphor derived imines was synthesised and evaluated in vitro for antiviral activity. Theoretical evaluations of ADME properties were also carried out. Most of these compounds exhibited significant activity against the drug-resistant strains of influenza A virus. Especially, compounds 2 (SI = 632) and 3 (SI = 417) presented high inhibition against influenza subtypes A/Puerto Rico/8/34 and A/California/07/09 of H1N1pdm09. Analysis of the structure-activity relationship showed that the activity was strongly dependent on the length of the aliphatic chain: derivatives with a shorter chain possessed higher activity, while the suppressing action of compounds with long aliphatic chains was lower. (C) 2016 Elsevier Masson SAS.
Cite:
Sokolova A.S.
, Yarovaya O.I.
, Baev D.S.
, Shernyukov A.V.
, Shtro A.A.
, Zarubaev V.V.
, Salakhutdinov N.F.
Aliphatic and alicyclic camphor imines as effective inhibitors of influenza virus H1N1
European Journal of Medicinal Chemistry. 2017. V.127. P.661-670. DOI: 10.1016/j.ejmech.2016.10.035 WOS Scopus РИНЦ OpenAlex
Aliphatic and alicyclic camphor imines as effective inhibitors of influenza virus H1N1
European Journal of Medicinal Chemistry. 2017. V.127. P.661-670. DOI: 10.1016/j.ejmech.2016.10.035 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Feb 1, 2017 |
Identifiers:
| Web of science: | WOS:000397172800053 |
| Scopus: | 2-s2.0-85006150304 |
| Elibrary: | 29471677 |
| OpenAlex: | W2539327824 |