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Light-Stimulated Generation of Free Radicals by Quinones-Chelators Научная публикация

Журнал Zeitschrift fur Physikalische Chemie -INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS
ISSN: 0942-9352 , E-ISSN: 1865-7117
Вых. Данные Год: 2017, Том: 231, Номер: 2, Страницы: 369-389 Страниц : DOI: 10.1515/zpch-2016-0831
Ключевые слова CIDNP; EPR; free radicals; metal chelation; photosynthetizers; quinones; spin traps
Авторы Markova Irina D. 1,2 , Polyakov Nikolay E. 1 , Selyutina Olga Yu. 1,2 , Fedenok Lidia G. 1 , Fedotov Kirill Yu. 1 , Slepneva Irina A. 1 , Leshina Tatyana V. 1 , Pokrovsky Andrey G. 2 , Vasilieva Nadezhda V. 3 , Weiner Lev M. 4
Организации
1 (Данные Web of science) Voevodsky Inst Chem Kinet & Combust SB RAS, Inst Skaya Str 3, Novosibirsk 630090, Russia
2 (Данные Web of science) Novosibirsk State Univ, Pirogova Str 2, Novosibirsk 630090, Russia
3 (Данные Web of science) NN Vorozhtsov Novosibirsk Inst Organ Chem, Lavrentieva Ave 9, Novosibirsk 630090, Russia
4 (Данные Web of science) Weizmann Inst Sci, Herzl St 234, IL-7610001 Rehovot, Israel

Реферат: The role of metal ions in the mechanism of light-stimulated redox activity of potential anticancer agent 2-phenyl-4-(butylamino) naphtha[2,3-h] quinoline-7,12-dione (Qc) has been studied by CIDNP (chemically induced dynamic nuclear polarization) and EPR methods. The photo-induced oxidation of NADH and its synthetic analog - substituted dihydropyridine (DHP) - by quinone Qc was used as a model. The Qc capability of producing chelating complexes with divalent metal ions of Fe, Zn and Ca was studied quantitatively by optical absorption spectroscopy. A significant decrease of electrochemical reduction potential of Qc (Delta E = 0.4 - 0.6 eV for ACN and ACN/PBS solutions) in chelating complexes and in protonated form of Qc was observed. A pronounced increase in efficiency of DHP oxidation in chelating complexes with Zn2+ and Ca2+ ions compared with free Qc was demonstrated. The yields of free radicals, including reactive oxygen species (ROS) and reaction products, were a few times higher than those in the absence of metal ions. Application of such chelating compounds to enhance ROS generation looks very promising for anti-cancer therapy, including the photodynamic therapy.
Библиографическая ссылка: Markova I.D. , Polyakov N.E. , Selyutina O.Y. , Fedenok L.G. , Fedotov K.Y. , Slepneva I.A. , Leshina T.V. , Pokrovsky A.G. , Vasilieva N.V. , Weiner L.M.
Light-Stimulated Generation of Free Radicals by Quinones-Chelators
Zeitschrift fur Physikalische Chemie -INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS. 2017. V.231. N2. P.369-389. DOI: 10.1515/zpch-2016-0831 WOS Scopus РИНЦ OpenAlex
Даты:
Опубликована online: 1 нояб. 2016 г.
Опубликована в печати: 1 янв. 2017 г.
Идентификаторы БД:
Web of science: WOS:000393576100012
Scopus: 2-s2.0-85012164094
РИНЦ: 29479333
OpenAlex: W2547241453
Цитирование в БД:
БД Цитирований
Web of science 10
Scopus 9
РИНЦ 11
OpenAlex 10
Альметрики: