New Cancer Cells Apoptosis Agents: Fluorinated Aza-Heterocycles Conference Abstracts
| Conference |
PHYSICS OF CANCER: INTERDISCIPLINARY PROBLEMS AND CLINICAL APPLICATIONS 23-26 May 2017 , Tomsk |
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| Journal |
AIP Conference Proceedings
ISSN: 0094-243X |
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| Output data | Year: 2017, Volume: 1882, Article number : 020057, Pages count : DOI: 10.1063/1.5001636 | ||||||
| Authors |
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| Affiliations |
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Abstract:
Fluorinated benzo-fused 1,3-diazoles, 1,2,3-triazoles, 1,2,5-thia/selenadiazoles and 1,4-diazines were synthesized and tried for cytotoxicity towards the Hep2 (laryngeal epidermoid carcinoma) cells. The diazoles, triazoles and selenadiazoles were cytotoxic with IC50 = 2.2-26.4 mu M and induced the cells apoptosis at concentrations C = 1-25 mu M. At the same time, they were nontoxic towards normal cells. Due to this, these scaffolds were used in the computer-aided molecular design of new antitumor agents. Particularly, novel 1,2,3-triazole and 1,3-diazole derivatives for the binding site of the PAS domain of the transcription factor HIF were designed and some of them synthesized for further study. Overall, new anticancer agents featuring apoptotic activity are suggested.
Cite:
Prima D.O.
, Baev D.S.
, Vorontsova E.V.
, Frolova T.S.
, Bagryanskaya I.Y.
, Slizhov Y.G.
, Tolstikova T.G.
, Makarov A.Y.
, Zibarev A.V.
New Cancer Cells Apoptosis Agents: Fluorinated Aza-Heterocycles
AIP Conference Proceedings. 2017. V.1882. 020057 . DOI: 10.1063/1.5001636 WOS Scopus РИНЦ OpenAlex
New Cancer Cells Apoptosis Agents: Fluorinated Aza-Heterocycles
AIP Conference Proceedings. 2017. V.1882. 020057 . DOI: 10.1063/1.5001636 WOS Scopus РИНЦ OpenAlex
Identifiers:
| Web of science: | WOS:000426914800057 |
| Scopus: | 2-s2.0-85041651665 |
| Elibrary: | 42765382 |
| OpenAlex: | W2756560073 |