Simple and efficient process for large scale preparation of betulonic acid from birch bark extracts Full article
| Journal |
Industrial Crops and Products
ISSN: 0926-6690 , E-ISSN: 1872-633X |
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| Output data | Year: 2016, Volume: 92, Pages: 197-200 Pages count : 4 DOI: 10.1016/j.indcrop.2016.07.026 | ||
| Tags | Betulonic acid; Betulin; Birch bark extraction; Extract oxidation | ||
| Authors |
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| Affiliations |
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Abstract:
A bioactive triterpenoid betulonic acid is a valuable synthone for preparation of lupane- and oleanane-type derivatives with a wide spectrum of medical applications. A large-scale, cost-effective, and simple preparation of betulonic acid from birch (Betula pendula) bark is presented herein. The process includes four steps with the acid overall yield of 51% counting on betulin content in the extract and with the acid purity of 90% or more. The process can be employed for batch production of betulonic acid. (C) 2016 Elsevier B.V. All rights reserved.
Cite:
Popov S.A.
, Kozlova L.P.
, Kornaukhova L.M.
, Shpatov A.V.
Simple and efficient process for large scale preparation of betulonic acid from birch bark extracts
Industrial Crops and Products. 2016. V.92. P.197-200. DOI: 10.1016/j.indcrop.2016.07.026 WOS Scopus РИНЦ OpenAlex
Simple and efficient process for large scale preparation of betulonic acid from birch bark extracts
Industrial Crops and Products. 2016. V.92. P.197-200. DOI: 10.1016/j.indcrop.2016.07.026 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Dec 1, 2016 |
Identifiers:
| Web of science: | WOS:000383821200023 |
| Scopus: | 2-s2.0-84981276955 |
| Elibrary: | 27134990 |
| OpenAlex: | W2515359892 |