Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents Full article
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Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388 |
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| Output data | Year: 2016, Volume: 52, Number: 5, Pages: 813-820 Pages count : 8 DOI: 10.1007/s10600-016-1785-2 | ||||
| Tags | monoterpenes; thiophenecarboxaldehyde; clay; heterocyclic compounds; analgesic activity | ||||
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Abstract:
Hexahydro-2H-chromenes with thiophene fragments were synthesized via reactions of a p-menthane monoterpenoid diol with several thiophenecarboxaldehydes. Most of the synthesized compounds with an additional thiophene fragment displayed analgesic activity in vivo tests at a dose of 10 mg/kg. It was found that the activity in either an acetate-writhing test or a hot-plate test depended on the type and location of substituent in the heteroaromatic ring.
Cite:
Pavlova A.V.
, Nazimova E.V.
, Mikhal'chenko O.S.
, Il'ina I.V.
, Korchagina D.V.
, Ardashov O.V.
, Morozova E.A.
, Tolstikova T.G.
, Volcho K.P.
, Salakhutdinov N.F.
Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents
Chemistry of Natural Compounds. 2016. V.52. N5. P.813-820. DOI: 10.1007/s10600-016-1785-2 WOS Scopus РИНЦ OpenAlex
Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents
Chemistry of Natural Compounds. 2016. V.52. N5. P.813-820. DOI: 10.1007/s10600-016-1785-2 WOS Scopus РИНЦ OpenAlex
Dates:
| Published online: | Aug 15, 2016 |
| Published print: | Sep 1, 2016 |
Identifiers:
| Web of science: | WOS:000381974900010 |
| Scopus: | 2-s2.0-85027945480 |
| Elibrary: | 41782363 |
| OpenAlex: | W2515890576 |