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Correlation of Metabolic Profiles of Plasma and Cerebrospinal Fluid of High-Grade Glioma Patients Научная публикация

Журнал Metabolites
ISSN: 2218-1989
Вых. Данные Год: 2021, Том: 11, Номер: 3, Номер статьи : 133, Страниц : DOI: 10.3390/metabo11030133
Ключевые слова glioma; metabolomics; liquid chromatography; tandem mass spectrometry; plasma; cerebrospinal fluid
Авторы Rogachev Artem D. 1,2 , Alemasov Nikolay A. 3 , Ivanisenko Vladimir A. 3 , Ivanisenko Nikita 3 , Gaisler Evgeniy 1 , Oleshko Olga S. 1 , Cheresiz Sergey 1 , Mishinov Sergey 4 , Stupak Vyacheslav V. 4 , Pokrovsky Andrey G. 1
Организации
1 (Данные Web of science) Novosibirsk State Univ, V Zelman Inst Med & Psychol, Pirogov Str 2, Novosibirsk 630090, Russia
2 (Данные Web of science) NN Vorozhtsov Novosibirsk Inst Organ Chem, Acad Lavrentiev Ave 9, Novosibirsk 630090, Russia
3 (Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Acad Lavrentiev Ave 10, Novosibirsk 630090, Russia
4 (Данные Web of science) FSBI Novosibirsk Res Inst Traumatol & Orthoped, Frunze Str 17, Novosibirsk 630091, Russia

Реферат: This work compares the metabolic profiles of plasma and the cerebrospinal fluid (CSF) of the patients with high-grade (III and IV) gliomas and the conditionally healthy controls using the wide-range targeted screening of low molecular metabolites by HPLC-MS/MS. The obtained data were analyzed using robust linear regression with Huber's M-estimates, and a number of metabolites with correlated content in plasma and CSF was identified. The statistical analysis shows a significant correlation of metabolite content in plasma and CSF samples for the majority of metabolites. Several metabolites were shown to have high correlation in the control samples, but not in the glioma patients. This can be due to the specific metabolic processes in the glioma patients or to the damaged integrity of blood-brain barrier. The results of our study may be useful for the understanding of molecular mechanisms underlying the development of gliomas, as well as for the search of potential biomarkers for the minimally invasive diagnostic procedures of gliomas.
Библиографическая ссылка: Rogachev A.D. , Alemasov N.A. , Ivanisenko V.A. , Ivanisenko N. , Gaisler E. , Oleshko O.S. , Cheresiz S. , Mishinov S. , Stupak V.V. , Pokrovsky A.G.
Correlation of Metabolic Profiles of Plasma and Cerebrospinal Fluid of High-Grade Glioma Patients
Metabolites. 2021. V.11. N3. 133 . DOI: 10.3390/metabo11030133 WOS Scopus РИНЦ OpenAlex
Файлы: Полный текст от издателя
Даты:
Опубликована online: 25 февр. 2021 г.
Идентификаторы БД:
Web of science: WOS:000633870700001
Scopus: 2-s2.0-85102735228
РИНЦ: 46768247
OpenAlex: W3131450525
Цитирование в БД:
БД Цитирований
Web of science 18
Scopus 13
РИНЦ 17
OpenAlex 23
Альметрики: