Synthesis, antiulcerative, and anti-inflammatory activities of new campholenic derivatives-1,3-thiazolidin-4-ones, 1,3-thiazolidine-2,4-diones, and 1,3-thiazinan-4-ones Full article
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Chemical Papers
ISSN: 0366-6352 , E-ISSN: 1336-9075 |
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| Output data | Year: 2021, Volume: 75, Pages: 5503–5514 Pages count : DOI: 10.1007/s11696-021-01741-5 | ||
| Tags | (-)-Campholenic aldehyde; Anti-inflammatory; Antiulcer; Thiazinanones; Thiazolidinediones; Thiazolidinones | ||
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Abstract:
In this paper, new thiazolidinones, thiazinanones, and thiazolidinediones based on a monoterpenoid (-)-campholenic aldehyde were synthesized and their antiulcer and anti-inflammatory activity was investigated. The thiazolidinones and thiazinanones containing a (-)-campholenic moiety have been shown to possess antiulcerogenic properties in indomethacin-induced ulcer test comparable to the activity of the reference drug omeprazole. None of the investigated thiazolidinediones showed antiulcerative activity in the test. One of the (-)-campholenic aldehyde-derived thiazolidinones has also demonstrated high anti-inflammatory activity on the histamine-induced inflammatory edema model similar to the activity of diclofenac. It is shown that changing a (-)-campholenic substituent for a linear aliphatic or a terpenic fragment with a pinane scaffold results in decreasing the pharmacological properties, though the (-)-campholenic moiety does not seem to make a key contribution to the pharmacological activity. Compounds 11 and 17 have been shown to exhibit antiulcer and anti-inflammatory action at a dose of 100 mg/kg. © 2021, Institute of Chemistry, Slovak Academy of Sciences.
Cite:
Borisova M.S.
, Ivankin D.I.
, Sokolov D.N.
, Luzina O.A.
, Rybalova T.V.
, Tolstikova T.G.
, Salakhutdinov N.F.
Synthesis, antiulcerative, and anti-inflammatory activities of new campholenic derivatives-1,3-thiazolidin-4-ones, 1,3-thiazolidine-2,4-diones, and 1,3-thiazinan-4-ones
Chemical Papers. 2021. V.75. P.5503–5514. DOI: 10.1007/s11696-021-01741-5 WOS Scopus РИНЦ OpenAlex
Synthesis, antiulcerative, and anti-inflammatory activities of new campholenic derivatives-1,3-thiazolidin-4-ones, 1,3-thiazolidine-2,4-diones, and 1,3-thiazinan-4-ones
Chemical Papers. 2021. V.75. P.5503–5514. DOI: 10.1007/s11696-021-01741-5 WOS Scopus РИНЦ OpenAlex
Dates:
| Published online: | Jun 18, 2021 |
Identifiers:
| Web of science: | WOS:000662874100002 |
| Scopus: | 2-s2.0-85108065239 |
| Elibrary: | 46819065 |
| OpenAlex: | W3177162844 |