Abstract: Three polymorphs of tolbutamide (I-L, II, and III) were studied using single-crystal X-ray diffraction, from 100 K to room temperature (forms II and III) and to 350 K (form I), and differential scanning calorimetry. The reversible transformation, I-L double left right arrow I-H, was found to be of the single-crystal to single-crystal type and the structure of the high-temperature form (I-H) was solved and refined. The structure of I-H differs from that of I-L only in the conformation of the molecule, with molecular arrangements being practically unchanged (isostructural conformational transformation). The transition takes place at 313 K with no sign of hysteresis. The volume change, Delta V/V, across the reversible transformation I-L double left right arrow I-H was calculated and compared to those for the other conformational transformations. Two types of conformational polymorphic transformations (irreversible reconstructive and reversible isostructural) in tolbutamide and chlorpropamide were compared.

Cite: Drebushchak T.N. , Drebushchak V.A. , Pankrushina N.A. , Boldyreva E.V.
Single-crystal to single-crystal conformational polymorphic transformation in tolbutamide at 313 K. Relation to other polymorphic transformations in tolbutamide and chlorpropamide
CrystEngComm. 2016. V.18. N30. P.5736-5743. DOI: 10.1039/c6ce00764c WOS Scopus РИНЦ OpenAlex

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Identifiers:

Web of science:	WOS:000381417700018
Scopus:	2-s2.0-84979902284
Elibrary:	27108275
OpenAlex:	W2439079067

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DB	Citing
Web of science	25
Scopus	24
Elibrary	25
OpenAlex	25

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