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nZ,(n+4) Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and II alpha Научная публикация

Журнал Medicinal Chemistry Research
ISSN: 1054-2523 , E-ISSN: 1554-8120
Вых. Данные Год: 2016, Том: 25, Номер: 1, Страницы: 30-39 Страниц : 10 DOI: 10.1007/s00044-015-1446-1
Ключевые слова Fatty acids; Cyclomagnesiation; Homogeneous catalysis; Topoisomerase I and II alpha inhibitors; Docking; Stereoselective synthesis of nZ,(n+4) Z-dienoic acids
Авторы D'yakonov Vladimir A. 1 , Dzhemileva Lilya U. 3 , Makarov Aleksey A. 1,2 , Mulyukova Alfiya R. 1,2 , Baev Dmitry S. 4 , Khusnutdinova Elza K. 5 , Tolstikova Tatiana G. 4 , Dzhemilev Usein M. 1,2
Организации
1 (Данные Web of science) Inst Petrochem, 141 Prospekt Oktyabrya, Ufa 450075, Bashkortostan, Russia
2 (Данные Web of science) Buryatia State Univ, 141 Prospekt Oktyabrya, Ufa 450075, Bashkortostan, Russia
3 (Данные Web of science) Bashkir State Med Univ, Dept Immunol & Humans Reprod Hlth, 3 Lenin St, Ufa 450003, Bashkortostan, Russia
4 (Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
5 (Данные Web of science) Bashkir State Univ, Dept Genet Fundamental Med, 32 Zaki Validi St, Ufa 450043, Bashkortostan, Russia

Реферат: An original, effective approach to the stereoselective method for the synthesis of higher unsaturated acids containing a 1Z, 5Z-diene group in 61-75 % yields and with >98 % selectivity based on the new intermolecular Cp2TiCl2-catalyzed cross-cyclomagnesiation of terminal aliphatic and O-containing 1,2-diene with Grignard reagents has been developed. The inhibitory action of the obtained dienoic acids on the human topoisomerase I and II was studied. Resorting to the data of molecular docking, a probable mechanism of inhibition was proposed.
Библиографическая ссылка: D'yakonov V.A. , Dzhemileva L.U. , Makarov A.A. , Mulyukova A.R. , Baev D.S. , Khusnutdinova E.K. , Tolstikova T.G. , Dzhemilev U.M.
nZ,(n+4) Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and II alpha
Medicinal Chemistry Research. 2016. V.25. N1. P.30-39. DOI: 10.1007/s00044-015-1446-1 WOS Scopus РИНЦ OpenAlex
Даты:
Опубликована online: 15 сент. 2015 г.
Опубликована в печати: 1 янв. 2016 г.
Идентификаторы БД:
Web of science: WOS:000368548500003
Scopus: 2-s2.0-84954377561
РИНЦ: 27036791
OpenAlex: W2261769784
Цитирование в БД:
БД Цитирований
Web of science 33
Scopus 33
РИНЦ 40
OpenAlex 41
Альметрики: