Inhibitory properties of nitrogen-containing adamantane derivatives with monoterpenoid fragments against tyrosyl-DNA phosphodiesterase 1 Full article
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Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620 |
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| Output data | Year: 2015, Volume: 41, Number: 6, Pages: 657-662 Pages count : DOI: 10.1134/S1068162015060199 | ||||||
| Tags | diazaadamantane; monoterpene; tyrosyl-DNA phosphodiesterase 1; inhibitor of DNA repair | ||||||
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Abstract:
The compounds containing diazaadamantane and monoterpene moieties have been found to inhibit human purified recombinant tyrosyl-DNA phosphodiesterase 1 (Tdp1), a DNA repair enzyme. Several compounds have been shown to be potent inhibitors of a new structural type. Improved inhibition efficiency has been observed for compounds with longer aliphatic chains and increased flexibility of substituent.
Cite:
Zakharenko A.L.
, Ponomarev K.U.
, Suslov E.V.
, Korchagina D.V.
, Volcho K.P.
, Vasil'eva I.A.
, Salakhutdinov N.F.
, Lavrik O.I.
Inhibitory properties of nitrogen-containing adamantane derivatives with monoterpenoid fragments against tyrosyl-DNA phosphodiesterase 1
Russian Journal of Bioorganic Chemistry. 2015. V.41. N6. P.657-662. DOI: 10.1134/S1068162015060199 WOS Scopus РИНЦ OpenAlex
Inhibitory properties of nitrogen-containing adamantane derivatives with monoterpenoid fragments against tyrosyl-DNA phosphodiesterase 1
Russian Journal of Bioorganic Chemistry. 2015. V.41. N6. P.657-662. DOI: 10.1134/S1068162015060199 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Nov 1, 2015 |
| Published online: | Nov 20, 2015 |
Identifiers:
| Web of science: | WOS:000365428700013 |
| Scopus: | 2-s2.0-84947922852 |
| Elibrary: | 24973776 |
| OpenAlex: | W2304584484 |