Hypolipidemic Berberine Derivatives with a Reduced Aromatic Ring C Full article
| Journal |
Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388 |
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| Output data | Year: 2015, Volume: 51, Number: 5, Pages: 916-922 Pages count : DOI: 10.1007/s10600-015-1447-9 | ||||
| Tags | berberine; isoquinoline alkaloids; tetrahydroisoquinoline; LDL receptors; Triton WR1339-induced hypercholesterolemia; hypolipidemic activity | ||||
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Abstract:
A series of aromatic and reduced berberine derivatives were synthesized. Their hypocholesterolemic activity was studied in vitro and in vivo. As a rule, berberine derivatives containing a reduced ring C were more capable of increasing the LDL receptor gene expression than the corresponding aromatic derivatives. Tests using a Triton WR1339-induced hypercholesterolemia model showed that 9-O-tosyltetrahydroberberine and 12-bromotetrahydroberberine possessed pronounced hypocholesterolemic activity and reduced the total cholesterol level by 33 and 27%; the triglyceride level, by 25 and 26%, respectively.
Cite:
Nechepurenko I.V.
, Boyarskikh U.A.
, Khvostov M.V.
, Baev D.S.
, Komarova N.I.
, Filipenko M.L.
, Tolstikova T.G.
, Salakhutdinov N.F.
Hypolipidemic Berberine Derivatives with a Reduced Aromatic Ring C
Chemistry of Natural Compounds. 2015. V.51. N5. P.916-922. DOI: 10.1007/s10600-015-1447-9 WOS Scopus РИНЦ OpenAlex
Hypolipidemic Berberine Derivatives with a Reduced Aromatic Ring C
Chemistry of Natural Compounds. 2015. V.51. N5. P.916-922. DOI: 10.1007/s10600-015-1447-9 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Sep 1, 2015 |
| Published online: | Oct 5, 2015 |
Identifiers:
| Web of science: | WOS:000362904300025 |
| Scopus: | 2-s2.0-84950236565 |
| Elibrary: | 26796443 |
| OpenAlex: | W2412258737 |