Synthesis and biological activity of novel deoxycholic acid derivatives Full article
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Bioorganic and Medicinal Chemistry
ISSN: 0968-0896 , E-ISSN: 1464-3391 |
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| Output data | Year: 2015, Volume: 23, Number: 15, Pages: 5022-5034 Pages count : DOI: 10.1016/j.bmc.2015.05.012 | ||||||
| Tags | Bile acids; Deoxycholic acid derivatives; Cytotoxicity; Nitric oxide; Biological activity | ||||||
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Abstract:
We report the synthesis and biological activity of new semi-synthetic derivatives of naturally occurring deoxycholic acid (DCA) bearing 2-cyano-3-oxo-1-ene, 3-oxo-1(2)-ene or 3-oxo-4(5)-ene moieties in ring A and 12-oxo or 12-oxo-9(11)-ene moieties in ring C. Bioassays using murine macrophage-like cells and tumour cells show that the presence of the 9(11)-double bond associated with the increased polarity of ring A or with isoxazole ring joined to ring A, improves the ability of the compounds to inhibit cancer cell growth. (C) 2015 Elsevier Ltd. All rights reserved.
Cite:
Popadyuk I.I.
, Markov A.V.
, Salomatina O.V.
, Logashenko E.B.
, Shernyukov A.V.
, Zenkova M.A.
, Salakhutdinov N.F.
Synthesis and biological activity of novel deoxycholic acid derivatives
Bioorganic and Medicinal Chemistry. 2015. V.23. N15. P.5022-5034. DOI: 10.1016/j.bmc.2015.05.012 WOS Scopus РИНЦ OpenAlex
Synthesis and biological activity of novel deoxycholic acid derivatives
Bioorganic and Medicinal Chemistry. 2015. V.23. N15. P.5022-5034. DOI: 10.1016/j.bmc.2015.05.012 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Aug 1, 2015 |
Identifiers:
| Web of science: | WOS:000358440000093 |
| Scopus: | 2-s2.0-84937513123 |
| Elibrary: | 23991725 |
| OpenAlex: | W2236053983 |