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Genotoxic and mutagenic properties of synthetic betulinic acid and betulonic acid Full article

Journal Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620
Output data Year: 2015, Volume: 41, Number: 4, Pages: 409-413 Pages count : DOI: 10.1134/S1068162015040056
Tags betulinic acid; betulonic acid; mutagenicity; genotoxicity; Ames test; SOS chromotest
Authors Frolova T. S. 1,2 , Kukina T. P. 2 , Sinitsyna O. I. 3
Affiliations
1 (Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
2 (Данные Web of science) Russian Acad Sci, Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk, Russia
3 (Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia

Abstract: Betulinic acid was synthesized from birch bark extract (Betula pendula), with betulonic acid being an intermediate of the synthesis. Both compounds were isolated with a purity of 95%. Genotoxicity and mutagenicity of the prepared compounds was analyzed by the Ames test and SOS chromotest and it was found that the substances show no mutagenic and genotoxic activity.
Cite: Frolova T.S. , Kukina T.P. , Sinitsyna O.I.
Genotoxic and mutagenic properties of synthetic betulinic acid and betulonic acid
Russian Journal of Bioorganic Chemistry. 2015. V.41. N4. P.409-413. DOI: 10.1134/S1068162015040056 WOS Scopus РИНЦ OpenAlex
Dates:
Published print: Jul 1, 2015
Published online: Jul 24, 2015
Identifiers:
Web of science: WOS:000358415100009
Scopus: 2-s2.0-84938086273
Elibrary: 23993699
OpenAlex: W2096540085
Citing:
DB Citing
Web of science 4
Scopus 4
Elibrary 5
OpenAlex 7
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