Abstract: Osteoarthritis and rheumatoid arthritis are the two most common types of arthritis. Cartilage breakdown is a key feature of both diseases which contributes to the pain and joint deformity experienced by patients. Therefore, anti-arthritis drugs are of great importance. The aim of this review is to present recent progress in studies of various agents against osteoarthritis and rheumatoid arthritis. The structures and activities of anti-arthritic agents, which used in medical practice or are in development, are presented and discussed. The effects and mechanisms of action of opioids, glucocorticoids, non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, natural products derived from plants, nutraceuticals, and a number of new and perspective agents are considered. Various perspective targets for the treatment of osteoarthritis and rheumatoid arthritis are also discussed. Trials of good quality are needed to draw solid conclusions regarding efficacy of many of the studied agents. Unfortunately, to date, there is no pharmacologic agent proven to prevent the progression of both diseases, and there is an urgent need for further development of better anti-arthritic agents. (C) 2015 Elsevier Ltd. All rights reserved.

Cite: Laev S.S. , Salakhutdinov N.F.
Anti-arthritic agents: Progress and potential
Bioorganic and Medicinal Chemistry. 2015. V.23. N13. P.3059-3080. DOI: 10.1016/j.bmc.2015.05.010 WOS Scopus РИНЦ OpenAlex

Dates:

Published print:

Jul 1, 2015

Identifiers:

Web of science:	WOS:000355848900010
Scopus:	2-s2.0-84937390660
Elibrary:	23991297
OpenAlex:	W272899553

Citing:

DB	Citing
Web of science	75
Scopus	73
Elibrary	75
OpenAlex	82

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