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Polysaccharide arabinogalactan from larch Larix sibirica as carrier for molecules of salicylic and acetylsalicylic acid: preparation, physicochemical and pharmacological study Научная публикация

Журнал Drug Delivery
ISSN: 1071-7544 , E-ISSN: 1521-0464
Вых. Данные Год: 2015, Том: 22, Номер: 3, Страницы: 400-407 Страниц : 8 DOI: 10.3109/10717544.2014.884655
Ключевые слова Complexation; mechanical activation; NMR; platelet aggregation; solid dispersion
Авторы Chistyachenko Yulia S. 1 , Dushkin Alexandr V. 1 , Polyakov Nikolay E. 2 , Khvostov Mikhail V. 3 , Tolstikova Tatyana G. 3 , Tolstikov Genrikh A. 3 , Lyakhov Nikolay Z. 1
Организации
1 (Данные Web of science) Inst Solid State Chem & Mechanochem, Novosibirsk 630128, Russia
2 (Данные Web of science) Russian Acad Sci, Inst Chem Kinet & Combust, Novosibirsk 630090, Russia
3 (Данные Web of science) NN Vorozhtsov Inst Organ Chem, Novosibirsk, Russia

Реферат: Inclusion complexes of salicylic acid (SA) and acetylsalicylic acid (aspirin, ASA) with polysaccharide arabinogalactan (AG) from larch wood Larix sibirica and Larix gmelinii were synthesized using mechanochemical technology. In the present study, we have investigated physicochemical properties of the synthesized complexes in solid state and in aqueous solutions as well as their anti-aggregation and ulcerogenic activity. The evidence of the complexes formation was obtained by nuclear magnetic resonance (NMR) relaxation technique. It was shown that in aqueous solution the molecules of SA and ASA are in fast exchange between the complex with AG macromolecules and solution. The stability constant of aspirin complex was calculated. It was shown that mechanochemically synthesized complexes are more stable when compared to the complex obtained by mixing solutions of the components. Complexes of ASA show two-fold increase of anti-platelet effect. It allows to reduce the dose of the antithrombotic drug and its ulcerogenic activity. These results substantiate the possibility to design new preparations on the basis of ASA with increased activity and safety.
Библиографическая ссылка: Chistyachenko Y.S. , Dushkin A.V. , Polyakov N.E. , Khvostov M.V. , Tolstikova T.G. , Tolstikov G.A. , Lyakhov N.Z.
Polysaccharide arabinogalactan from larch Larix sibirica as carrier for molecules of salicylic and acetylsalicylic acid: preparation, physicochemical and pharmacological study
Drug Delivery. 2015. V.22. N3. P.400-407. DOI: 10.3109/10717544.2014.884655 WOS Scopus РИНЦ OpenAlex
Даты:
Опубликована online: 12 февр. 2014 г.
Опубликована в печати: 3 апр. 2015 г.
Идентификаторы БД:
Web of science: WOS:000355764900019
Scopus: 2-s2.0-84930434403
РИНЦ: 24042948
OpenAlex: W2114341547
Цитирование в БД:
БД Цитирований
Web of science 35
Scopus 36
РИНЦ 45
OpenAlex 36
Альметрики: