The short way to chiral compounds with hexahydrofluoreno[9,1-bc]furan framework: Synthesis and cytotoxic activity Full article
| Journal |
Bioorganic and Medicinal Chemistry
ISSN: 0968-0896 , E-ISSN: 1464-3391 |
||||
|---|---|---|---|---|---|
| Output data | Year: 2015, Volume: 23, Number: 7, Pages: 1472-1480 Pages count : DOI: 10.1016/j.bmc.2015.02.013 | ||||
| Tags | Cytotoxicity; Antitumor activity; Terpene; Carene; Heterocycle; Apoptosis; Clay | ||||
| Authors |
|
||||
| Affiliations |
|
Abstract:
A simple and efficient method for synthesizing chiral heterocyclic compounds with the hexahydrofluoreno[9,1-bc]furan framework via interaction between trans-4-hydroxymethyl-2-carene and aromatic aldehydes containing methoxy and hydroxyl moieties in the presence of montmorillonite clay was found. One of the synthesized compounds exhibited a high cytotoxic activity against lymphoblastoid cell line MT-4 (CTD50 0.9 mu M), which was higher than that of the comparative drug Doxorubicin. Death of cancer cells in this case substantially occurs via induction of apoptosis. (C) 2015 Elsevier Ltd. All rights reserved.
Cite:
Kurbakova S.Y.
, Il'ina I.V.
, Mikhalchenko O.S.
, Pokrovsky M.A.
, Korchagina D.V.
, Volcho K.P.
, Pokrovsky A.G.
, Salakhutdinov N.F.
The short way to chiral compounds with hexahydrofluoreno[9,1-bc]furan framework: Synthesis and cytotoxic activity
Bioorganic and Medicinal Chemistry. 2015. V.23. N7. P.1472-1480. DOI: 10.1016/j.bmc.2015.02.013 WOS Scopus РИНЦ OpenAlex
The short way to chiral compounds with hexahydrofluoreno[9,1-bc]furan framework: Synthesis and cytotoxic activity
Bioorganic and Medicinal Chemistry. 2015. V.23. N7. P.1472-1480. DOI: 10.1016/j.bmc.2015.02.013 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Apr 1, 2015 |
Identifiers:
| Web of science: | WOS:000350995500012 |
| Scopus: | 2-s2.0-84925505642 |
| Elibrary: | 24019742 |
| OpenAlex: | W1969972600 |