Synthesis and Biological Activity of 4H-Thieno[3,2-c]Chromene Derivatives

Synthesis and Biological Activity of 4H-Thieno[3,2-c]Chromene Derivatives Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 0009-3122 , E-ISSN: 1573-8353

Output data

Year: 2015, Volume: 50, Number: 12, Pages: 1712-1718 Pages count : DOI: 10.1007/s10593-015-1642-4

Tags

4H-thieno[3,2-c]chromene; antiulcer activity; electrophilic substitution; oxidation; reduction

Authors

Bogza Yu. P. ¹ , Katsiel' A. L. ¹ , Sharypova A. N. ¹ , Tolstikova T. G. ² , Fisyuk A. S. ^1,3

Affiliations

1	(Данные Web of science) FM Dostoevskii Omsk State Univ, Omsk 644077, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
3	(Данные Web of science) Omsk State Tech Univ, Omsk 644050, Russia

The formyl group of 4H-thieno[3,2-c]chromene-2-carbaldehyde was transformed into the respective nitrile, amide, ester, carboxylic, hydroxamic, or hydroxy group. Electrophilic substitution in 4H-thieno[3,2-c]chromene-2-carbaldehyde was shown to occur at the D-8 atom, while oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in methanol led to 4-methoxy-4H-thieno[3,2-c]chromene-2-carbaldehyde. The latter compound was found to possess high antiulcer activity.

Bogza Y.P. , Katsiel' A.L. , Sharypova A.N. , Tolstikova T.G. , Fisyuk A.S.
Synthesis and Biological Activity of 4H-Thieno[3,2-c]Chromene Derivatives
Chemistry of Heterocyclic Compounds. 2015. V.50. N12. P.1712-1718. DOI: 10.1007/s10593-015-1642-4 WOS Scopus РИНЦ OpenAlex

Published online:	Jan 31, 2015
Published print:	Mar 1, 2015

Web of science:	WOS:000349913000009
Scopus:	2-s2.0-84953358616
Elibrary:	27568531
OpenAlex:	W1968192366

DB	Citing
Web of science	8
Scopus	10
Elibrary	10
OpenAlex	11