Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections

Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Вых. Данные

Год: 2019, Том: 68, Номер: 5, Страницы: 1041-1046 Страниц : 6 DOI: 10.1007/s11172-019-2517-0

Ключевые слова

Marburg virus; Ebola virus; pseudotyped viruses; (1S)-(+)-camphor-10-sulfonic acid; N-heterocycles; molecular docking

Авторы

Sokolova A.S. ¹ , Baranova D.V. ^1,2 , Yarovaya O.I. ^1,2 , Baev D.S. ^1,2 , Polezhaeva O.A. ³ , Zybkina A.V. ³ , Shcherbakov D.N. ³ , Tolstikova T.G. ^1,2 , Salakhutdinov N.F. ^1,2

Организации

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Akad Lavrenteva, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, 2 Ul Pirogova, Novosibirsk 630090, Russia
3	(Данные Web of science) State Res Ctr Virol & Biotechnol Vector, Koltsov 630559, Novosibirsk Reg, Russia

N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A molecular modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.

Sokolova A.S. , Baranova D.V. , Yarovaya O.I. , Baev D.S. , Polezhaeva O.A. , Zybkina A.V. , Shcherbakov D.N. , Tolstikova T.G. , Salakhutdinov N.F.
Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections
Russian Chemical Bulletin. 2019. V.68. N5. P.1041-1046. DOI: 10.1007/s11172-019-2517-0 WOS Scopus РИНЦ

Соколова А.С. , Баранова Д.В. , Яровая О.И. , Баев Д.С. , Полежаева О.А. , Зыбкина А.В. , Щербаков Д.Н. , Толстикова Т.Г. , Салахутдинов Н.Ф.
Синтез производных (1s)-(+)-камфора-10-сульфокислоты и изучение их противовирусной активности в качестве ингибиторов филовирусных инфекций in vitro и in silico
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2019. №5. С.1041-1046. РИНЦ

Опубликована в печати:	1 мая 2019 г.
Опубликована online:	11 июн. 2019 г.

Web of science	WOS:000471201700015
Scopus	2-s2.0-85067183336
РИНЦ	41633816
OpenAlex	W2949180311