Soluble chitosan-carrageenan polyelectrolyte complexes and their gastroprotective activity

Soluble chitosan-carrageenan polyelectrolyte complexes and their gastroprotective activity Научная публикация

Журнал

Carbohydrate Polymers
ISSN: 0144-8617 , E-ISSN: 1879-1344

Вых. Данные

Год: 2014, Том: 101, Страницы: 1087-1093 Страниц : DOI: 10.1016/j.carbpol.2013.10.049

Ключевые слова

Polyelectrolyte complex; Chitosan; Carrageenan; Supramolecular structure; AFM; Gastroprotective activity

Авторы

Volod'ko A. V. ¹ , Davydova V. N. ¹ , Chusovitin E. ² , Sorokina I. V. ³ , Dolgikh M. P. ³ , Tolstikova T. G. ³ , Balagan S. A. ^2,4 , Galkin N. G. ^2,4 , Yermak I. M. ¹

Организации

1	(Данные Web of science) Russian Acad Sci, Far East Branch, GB Elyakov Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia
2	(Данные Web of science) Russian Acad Sci, Far Eastern Branch, Inst Automat & Control Proc, Vladivostok 690041, Russia
3	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
4	(Данные Web of science) Far Eastern Fed Univ, Vladivostok 690950, Russia

The soluble polyelectrolyte complexes (PEC) kappa-carrageenan (kappa-CG):chitosan was obtained. Binding constant value (2.11 x 10(7) mol(-1)) showed high affinity of kappa-CG to chitosan. The complex formation of kappa-CG:chitosan 1:10 and 10:1 w/w was shown by centrifugation in a Percoll gradient. Using atomic force microscopy we showed that the supramolecular structure of the complexes is different from each other and from the macromolecular structure of the initial polysaccharides. The gastroprotective and anti-ulcerogenic effect of kappa-CG, chitosan and their complexes was investigated on the model of stomach ulcers induced by indometacin in rats. PEC kappa-CG:chitosan have gastroprotective properties which depend on their composition. Complex kappa-CG:chitosan I :10 w/w possesses higher gastroprotective activity than the complex 10:1 w/w. These results suggest that the gastroprotective effect of complexes can be associated with their protective layer on the surface of the mucous membrane of a stomach, which avoids a direct contact with the ulcerogenic agent. (C) 2013 Elsevier Ltd. All rights reserved.

Volod'ko A.V. , Davydova V.N. , Chusovitin E. , Sorokina I.V. , Dolgikh M.P. , Tolstikova T.G. , Balagan S.A. , Galkin N.G. , Yermak I.M.
Soluble chitosan-carrageenan polyelectrolyte complexes and their gastroprotective activity
Carbohydrate Polymers. 2014. V.101. P.1087-1093. DOI: 10.1016/j.carbpol.2013.10.049 WOS Scopus РИНЦ

Опубликована в печати:

1 янв. 2014 г.

Web of science	WOS:000330494800137
Scopus	2-s2.0-84887198742
РИНЦ	21861085
OpenAlex	W1972528761