Discovery of new ginsenol-like compounds with high antiviral activity

Discovery of new ginsenol-like compounds with high antiviral activity Научная публикация

Журнал

Molecules
, E-ISSN: 1420-3049

Вых. Данные

Год: 2021, Том: 26, Номер: 22, Номер статьи : 6794, Страниц : DOI: 10.3390/molecules26226794

Ключевые слова

Antiviral agent; Ginsamide; Ginsenol; Influenza; Molecular modeling; Resistance; Surface protein

Авторы

Volobueva A.S. ¹ , Yarovaya O.I. ² , Kireeva M.V. ³ , Borisevich S.S. ⁴ , Kovaleva K.S. ² , Mainagashev I.Ya. ² , Gatilov Y.V. ² , Ilyina M.G. ⁴ , Zarubaev V.V. ¹ , Salakhutdinov N.F. ²

Организации

1	Laboratory of Experimental Virology Pasteur, Institute of Epidemiology and Microbiology, 14 Mira Str., St. Petersburg, 197101, Russian Federation
2	Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, Novosibirsk, 630090, Russian Federation
3	Biology Department, St. Petersburg State University, 7/9 Universitetskaya Nab, St. Petersburg, 199034, Russian Federation
4	Laboratory of Chemical Physics, Ufa Institute of Chemistry Ufa Federal Research Center, 71 Pr. Oktyabrya, Ufa, 450078, Russian Federation

A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which was confirmed using an animal model. Biological experiments were performed to determine the mechanism of action of the new agents, a ginsamide-resistant strain of influenza virus was obtained, and the pathogenicity of the resistant strain and the control strain was studied. It was shown that the emergence of resistance to Ginsamide was accompanied by a reduction in the pathogenicity of the influenza virus. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Volobueva A.S. , Yarovaya O.I. , Kireeva M.V. , Borisevich S.S. , Kovaleva K.S. , Mainagashev I.Y. , Gatilov Y.V. , Ilyina M.G. , Zarubaev V.V. , Salakhutdinov N.F.
Discovery of new ginsenol-like compounds with high antiviral activity
Molecules. 2021. V.26. N22. 6794 . DOI: 10.3390/molecules26226794 WOS Scopus

Web of science	WOS:000815305600001
Scopus	2-s2.0-85119589192
OpenAlex	W3212583477