Complex Investigation of the Effects of Lambertianic Acid Amide in Female Mice under Conditions of Social Discomfort

Complex Investigation of the Effects of Lambertianic Acid Amide in Female Mice under Conditions of Social Discomfort Научная публикация

Журнал

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Вых. Данные

Год: 2014, Том: 157, Номер: 5, Страницы: 583-587 Страниц : 5 DOI: 10.1007/s10517-014-2621-y

Ключевые слова

female mice; social discomfort; lambertianic acid derivatives

Авторы

Avgustinovich D.F. ^1,2 , Fomina M.K. ³ , Sorokina I.V. ³ , Tolstikova T.G. ³

Организации

1	(Данные Web of science) Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Div, Res Inst Physiol & Fundamental Med, Novosibirsk, Russia
3	(Данные Web of science) Russian Acad Sci, Siberian Div, NN Vorozhtsov Novosibirsk Inst Organ Chem, Moscow 117901, Russia

The effects of chronic administration of a new substance lambertianic acid amide and previously synthesized methyl ester of this acid were compared in female mice living under conditions of social discomfort. For modeling social discomfort, female mouse was housed for 30 days in a cage with aggressive male mouse kept behind a transparent perforated partition and observed its confrontations with another male mouse daily placed to the cage. The new agent more effectively than lambertianic acid methyl ester improved communicativeness and motor activity of animals, reduced hypertrophy of the adrenal glands, and enhanced catalase activity in the blood. These changes suggest that lambertianic acid amide produces a pronounced stress-protective effect under conditions of social discomfort.

Avgustinovich D.F. , Fomina M.K. , Sorokina I.V. , Tolstikova T.G.
Complex Investigation of the Effects of Lambertianic Acid Amide in Female Mice under Conditions of Social Discomfort
Bulletin of Experimental Biology and Medicine. 2014. V.157. N5. P.583-587. DOI: 10.1007/s10517-014-2621-y WOS Scopus РИНЦ

Августинович Д.Ф. , Маренина М.К. , Сорокина И.В. , Толстикова Т.Г.
Комплексное исследование эффектов амида ламбертиановой кислоты у самок мышей, находящихся в условиях социального дискомфорта
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2014. Т.157. №5. С.599-603. РИНЦ

Опубликована в печати:	1 сент. 2014 г.
Опубликована online:	26 сент. 2014 г.

Web of science	WOS:000343135900013
Scopus	2-s2.0-84921937405
РИНЦ	22775346
OpenAlex	W1977995228