Synthesis of berberine derivatives and their antiviral activity toward respiratory syncytial virus

Synthesis of berberine derivatives and their antiviral activity toward respiratory syncytial virus Научная публикация

Журнал

Medicinal Chemistry Research
ISSN: 1054-2523 , E-ISSN: 1554-8120

Вых. Данные

Год: 2023, Том: 32, Номер: 11, Страницы: 2325-2333 Страниц : 9 DOI: 10.1007/s00044-023-03138-3

Авторы

Shtro Anna A. ¹ , Gladkova Elizaveta D. ² , Galochkina Anastasia V. ¹ , Nikolaeva Yulia V. ¹ , Garshinina Angelika V. ¹ , Razgulyaeva Darya N. ¹ , Sorokin Evgeniy V. ¹ , Tsareva Tatyana R. ¹ , Luzina Olga A. ² , Salakhutdinov Nariman F. ²

Организации

1	Федеральное государственное бюджетное учреждение Научно-исследовательский институт гриппа им. А.А. Смородинцева Минздрава России
2	Новосибирский институт органической химии им. Н.Н. Ворожцова СО РАН

Информация о финансировании (1)

Российский Научный Фонд

21-13-00026

A series of derivatives of berberine was synthesized to estimate their antiviral activity toward respiratory syncytial virus. Berberine and its hydrogenated analogs were modified at different positions with various substituents. The antiviral activity of berberine and its derivatives against respiratory syncytial virus strain A2 was studied in vitro. Berberine itself and its 12-nitro and 9-O derivatives having heterocyclic motifs in the substituent were shown to have the highest antiviral activity, with half-maximal inhibitory concentration in the lower range (<10 μM). It was found that half-maximal cytotoxic concentration of the compounds varies widely, from 9 to >2000 μM. The selectivity of most compounds under study was below a desired threshold; only berberine, 12-nitroberberine, and tetrahydroberberine can be considered promising for the development of drugs for respiratory syncytial infection.

Shtro A.A. , Gladkova E.D. , Galochkina A.V. , Nikolaeva Y.V. , Garshinina A.V. , Razgulyaeva D.N. , Sorokin E.V. , Tsareva T.R. , Luzina O.A. , Salakhutdinov N.F.
Synthesis of berberine derivatives and their antiviral activity toward respiratory syncytial virus
Medicinal Chemistry Research. 2023. V.32. N11. P.2325-2333. DOI: 10.1007/s00044-023-03138-3 РИНЦ

Поступила в редакцию:	13 июн. 2023 г.
Принята к публикации:	7 авг. 2023 г.
Опубликована в печати:	18 авг. 2023 г.

РИНЦ	63748146
OpenAlex	W4385971186