Generation, inhalation delivery and anti-hypertensive effect of nisoldipine nanoaerosol

Generation, inhalation delivery and anti-hypertensive effect of nisoldipine nanoaerosol Научная публикация

Журнал

Journal of Aerosol Science
ISSN: 0021-8502 , E-ISSN: 1879-1964

Вых. Данные

Год: 2014, Том: 78, Страницы: 41-54 Страниц : DOI: 10.1016/j.jaerosci.2014.08.004

Ключевые слова

Evaporation-nucleation route; Nanoerosol lung deposition; Pulmonary delivery; Nisoldipine

Авторы

Onischuk A. A. ^1,2 , Tolstikova T. G. ^2,3 , Baklanov A. M. ¹ , Khvostov M. V. ³ , Sorokina I. V. ³ , Zhukova N. A. ³ , An'kov S. V. ³ , Borovkova O. V. ¹ , Dultseva G. G. ^1,2 , Boldyrev V. V. ^2,4 , Fomin V. M. ^2,5 , Huang G. Steven ⁶

Организации

1	(Данные Web of science) RAS, Inst Chem Kinet & Combust, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
3	(Данные Web of science) RAS, Inst Organ Chem, Novosibirsk 630090, Russia
4	(Данные Web of science) RAS, Inst Solid State Chem & Mechnochem, Novosibirsk 630090, Russia
5	(Данные Web of science) RAS, Inst Theoret & Appl Mech, Novosibirsk 630090, Russia
6	(Данные Web of science) Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu, Taiwan

Nisoldipine is a dihydropyridine subclass calcium channel blocker with low oral bioavailability. Therefore, novel drug delivery systems able to enhance nisoldipine bioavailability are urgently needed. Here the nanoaerosol pulmonary administration of nisoldipine is investigated in experiments with WISTAR and ISIAH rats. The drug aerosol inhalation scheme includes an evaporation-condensation aerosol generator, inhalation chambers for rats, and aerosol spectrometer (to control aerosol concentration and size distribution). The particle mean diameter and number concentration are within the ranges 10-200 nm and 10(3)-2 x 10(7) cm(-3), respectively. The chemical composition of nanoaerosol particles was shown by means of liquid chromatography to be identical with the maternal drug. Using nose-only exposure chambers, the rat lung deposition efficiency was evaluated as a function of particle diameter. The dose-dependent effect from aerosolized nisoldipine was compared with that from the intravenous and oral drug delivery. In particular, it was found that nisoldipine aerosol administration is essentially more effective than traditional oral treatment, i.e. it gives the same blood pressure reduction as the oral treatment at the body deposited dose about 100 times less. (C) 2014 Elsevier Ltd. All rights reserved.

Onischuk A.A. , Tolstikova T.G. , Baklanov A.M. , Khvostov M.V. , Sorokina I.V. , Zhukova N.A. , An'kov S.V. , Borovkova O.V. , Dultseva G.G. , Boldyrev V.V. , Fomin V.M. , Huang G.S.
Generation, inhalation delivery and anti-hypertensive effect of nisoldipine nanoaerosol
Journal of Aerosol Science. 2014. V.78. P.41-54. DOI: 10.1016/j.jaerosci.2014.08.004 WOS Scopus РИНЦ

Опубликована в печати:

1 дек. 2014 г.

Web of science	WOS:000347025100004
Scopus	2-s2.0-84907978465
РИНЦ	23994492
OpenAlex	W2007248154