Chiral N-(Octahydro-2H-chromen-4-yl)-2-(dialkylamino)acetamides: Synthesis and Analgesic Activity Научная публикация
Журнал |
Doklady Chemistry
ISSN: 0012-5008 |
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Вых. Данные | Год: 2023, Том: 512, Номер: 1, Страницы: 242-248 Страниц : 7 DOI: 10.1134/s0012500823600694 | ||||
Ключевые слова | isopulegol, Prins–Ritter reaction, octahydro-2H-chromene, analgesic activity | ||||
Авторы |
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Организации |
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Реферат:
A number of new derivatives of octahydro-2H-chromene based on monoterpenoid (–)-isopulegol has been synthesized. The composition and structure of the products have been established using NMR spectroscopy, high-resolution mass spectrometry, and X-ray diffraction analysis. It has been shown that the majority of obtained compounds show high analgesic activity in vivo. (4S)‑Diastereomers of morpholinoacetamide derivatives of octahydro-2H-chromene showed the highest efficiency in both tests (acetic acid-induced writhing test and hot plate test).
Библиографическая ссылка:
Li-Zhulanov N.S.
, Nikolaichuk K.M.
, Gatilov Y.V.
, Volcho K.P.
, Khvostov M.V.
, Tolstikova T.G.
, Salakhutdinov N.F.
Chiral N-(Octahydro-2H-chromen-4-yl)-2-(dialkylamino)acetamides: Synthesis and Analgesic Activity
Doklady Chemistry. 2023. V.512. N1. P.242-248. DOI: 10.1134/s0012500823600694 РИНЦ
Chiral N-(Octahydro-2H-chromen-4-yl)-2-(dialkylamino)acetamides: Synthesis and Analgesic Activity
Doklady Chemistry. 2023. V.512. N1. P.242-248. DOI: 10.1134/s0012500823600694 РИНЦ
Даты:
Поступила в редакцию: | 25 нояб. 2022 г. |
Принята к публикации: | 16 янв. 2023 г. |
Опубликована в печати: | 25 дек. 2023 г. |
Идентификаторы:
РИНЦ | 64393162 |
OpenAlex | W4390191010 |