Correction of Drug-Induced Hepatotoxicity with New Triterpene Derivatives in Transplanted RLS Lymphoma

Correction of Drug-Induced Hepatotoxicity with New Triterpene Derivatives in Transplanted RLS Lymphoma Научная публикация

Журнал

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Вых. Данные

Год: 2013, Том: 154, Номер: 3, Страницы: 370-374 Страниц : DOI: 10.1007/s10517-013-1953-3

Ключевые слова

RLS lymphoma metastases to mouse liver; polychemotherapy; hepatoprotective effect; betulin 3 beta,28-di-O-nicotinate (of3); 3,20-dioximino-29-norlup-28-ic acid methyl ester (of15)

Авторы

Zhukova N. A. ¹ , Semenov D. E. ² , Bessergeneva E. P. ¹ , Sorokina I. V. ¹ , Tolstikova T. G. ¹

Организации

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Inst Organ Chem, Siberian Div, Novosibirsk, Russia
2	(Данные Web of science) Russian Acad Med Sci, Inst Reg Pathol & Pathomorphol, Siberian Div, Novosibirsk, Russia

The hepatoprotective effects of new triterpene derivatives, betulin 3 beta,28-di-O-nicotinate (of3) and 3,20-dioximino-29-norlup-28-ic acid methyl ester (of15), were studied in CBA/Lac mice with transplanted RLS lymphoma receiving polychemotherapy and without it. Injection of of3 and of15 agents to animals with tumors receiving polychemotherapy reduced the severity of toxic involvement of the liver, reduced mitotic activity of tumor cells in the primary node in animals receiving and not polychemotherapy, and produced a moderate antitumor effect. These effects were more pronounced for of15 agent. In addition, injection of agents of3 and of5 to animals with transplanted RLS lymphoma reduced the intensity of alterations associated with the total systems and local effects of the neoplastic process.

Zhukova N.A. , Semenov D.E. , Bessergeneva E.P. , Sorokina I.V. , Tolstikova T.G.
Correction of Drug-Induced Hepatotoxicity with New Triterpene Derivatives in Transplanted RLS Lymphoma
Bulletin of Experimental Biology and Medicine. 2013. V.154. N3. P.370-374. DOI: 10.1007/s10517-013-1953-3 WOS Scopus РИНЦ

Жукова Н.А. , Семенов Д.Е. , Бессергенева Е.П. , Сорокина И.В. , Толстикова Т.Г.
Коррекция лекарственно-индуцированной гепатотоксичности новыми тритерпеновыми производными при перевиваемой лимфоме RLS
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2012. Т.154. №9. С.356-360. РИНЦ

Опубликована в печати:	1 янв. 2013 г.
Опубликована online:	16 янв. 2013 г.

Web of science	WOS:000314022600020
Scopus	2-s2.0-84873058981
РИНЦ	20424647
OpenAlex	W2099474289