3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains

3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains Научная публикация

Журнал

Molecules
, E-ISSN: 1420-3049

Вых. Данные

Год: 2022, Том: 27, Номер: 6, Страницы: 1922 Страниц : 1 DOI: 10.3390/molecules27061922

Ключевые слова

nitroxides; nitrones; organometallic compounds; pyrrolidine; reduction kinetics

Авторы

Taratayko Andrey I. ¹ , Glazachev Yurii I. ² , Eltsov Ilia V. ³ , Chernyak Elena I. ¹ , Kirilyuk Igor A. ¹

Организации

1	N.N. Vorozhtsov Institute of Organic Chemistry SB RAS
2	Voevodsky Institute of Chemical Kinetics and Combustion SB RAS
3	Department of Natural Sciences, Novosibirsk State University

Информация о финансировании (1)

Российский Научный Фонд

21-73-00281

Pyrrolidine nitroxides with four bulky alkyl substituents adjacent to N–O group are known for their high resistance to bioreduction. The 3,4-unsubstituted 2-tert-butyl-2-ethylpyrrolidine-1-oxyls were prepared from the corresponding 2-tert-butyl-1-pyrroline-1-oxides via either the addition of ethinylmagnesium bromide with subsequent hydrogenation or via treatment with ethyllithium. The new nitroxides showed excellent stability to reduction with ascorbate with no evidence for additional large hyperfine couplings in the EPR spectra.

Taratayko A.I. , Glazachev Y.I. , Eltsov I.V. , Chernyak E.I. , Kirilyuk I.A.
3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains
Molecules. 2022. V.27. N6. P.1922. DOI: 10.3390/molecules27061922 WOS РИНЦ

Поступила в редакцию:	18 февр. 2022 г.
Принята к публикации:	15 мар. 2022 г.
Опубликована online:	16 мар. 2022 г.

Web of science	WOS:000774374100001
РИНЦ	48419935
OpenAlex	W4220939429