Analgesic Effect from Ibuprofen Nanoparticles Inhaled by Male Mice

Analgesic Effect from Ibuprofen Nanoparticles Inhaled by Male Mice Научная публикация

Журнал

Journal of Aerosol Medicine and Pulmonary Drug Delivery
ISSN: 1941-2711 , E-ISSN: 1941-2703

Вых. Данные

Год: 2009, Том: 22, Номер: 3, Страницы: 245-253 Страниц : DOI: 10.1089/jamp.2008.0721

Ключевые слова

ibuprofen; nanoparticles; aerosol drug administration; particle lung deposition; mice; analgesic effect

Авторы

Onischuk Andrei A. ¹ , Tolstikova Tatyana G. ² , Sorokina Irina V. ² , Zhukova Natalya A. ² , Baklanov Anatoly M. ¹ , Karasev Vladimir V. ¹ , Borovkova Olga V. ¹ , Dultseva Galina G. ¹ , Boldyrev Vladimir V. ^3,4 , Fomin Vasilii M. ⁵

Организации

1	(Данные Web of science) Russian Acad Sci, Inst Chem Kinet & Combust, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Inst Organ Chem, Novosibirsk 630090, Russia
3	(Данные Web of science) Novosibirsk State Univ, Sci & Educ Ctr Mol Design & Ecologically Safe Tec, Novosibirsk, Russia
4	(Данные Web of science) Russian Acad Sci, Inst Solid State Chem & Mechanochem, Novosibirsk 630090, Russia
5	(Данные Web of science) Russian Acad Sci, Inst Theoret & Appl Mech, Novosibirsk 630090, Russia

Background: Aerosol lung administration is a convenient way to deliver water-insoluble or poorly soluble drugs, provided that small-sized particles are generated. Here, for the outbred male mice, we show that the pulmonary administration of ibuprofen nanoparticles requires a dose that is three to five orders of magnitude less than that for the orally delivered particles at the same analgesic effect. Method: The aerosol evaporation-condensation generator consisted of a horizontal cylindrical quartz tube with an outer heater. Argon flow was supplied to the inlet and aerosol was formed at the outlet. The particle mean diameter and number concentration varied from 10 to 100 nm and 10(3) - 10(7) cm(-3), respectively. The analgesic action and side pulmonary effects caused by the inhalation of ibuprofen nanoparticles were investigated. Results: The chemical composition of aerosol particles was shown to be identical with the maternal drug. Using the nose-only exposure chambers, the mice lung deposition efficiency was evaluated as a function of the particle diameter. Conclusions: The dose-dependent analgesic effect of aerosolized ibuprofen was studied in comparison with the oral treatment. It was found that the dose for aerosol treatment is three to five orders of magnitude less than that required for oral treatment at the same analgesic effect. Accompanying effects were moderate venous hyperemia and some emphysematous signs.

Onischuk A.A. , Tolstikova T.G. , Sorokina I.V. , Zhukova N.A. , Baklanov A.M. , Karasev V.V. , Borovkova O.V. , Dultseva G.G. , Boldyrev V.V. , Fomin V.M.
Analgesic Effect from Ibuprofen Nanoparticles Inhaled by Male Mice
Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2009. V.22. N3. P.245-253. DOI: 10.1089/jamp.2008.0721 WOS Scopus РИНЦ

Опубликована в печати:

1 сент. 2009 г.

Web of science	WOS:000269794700004
Scopus	2-s2.0-70349279195
РИНЦ	15309890
OpenAlex	W2031106481