Effects of Acute and Chronic Treatment of Novel Psychotropic Drug, 8-(Trifluoromethyl)-1, 2, 3, 4, 5-benzopentathiepin-6-amine Hydrochloride (TC-2153), on the Behavior of Zebrafish (Danio Rerio): A Comparison with Fluoxetine

Effects of Acute and Chronic Treatment of Novel Psychotropic Drug, 8-(Trifluoromethyl)-1, 2, 3, 4, 5-benzopentathiepin-6-amine Hydrochloride (TC-2153), on the Behavior of Zebrafish (Danio Rerio): A Comparison with Fluoxetine Научная публикация

Журнал

Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X

Вых. Данные

Год: 2019, Том: 16, Номер: 12, Страницы: 1321-1328 Страниц : 8 DOI: 10.2174/1570180816666190221162952

Ключевые слова

TC-2153; fluoxetine; acute treatment; chronic treatment; anxiolytic-like effect; novel tank test; zebrafish

Авторы

Kulikov Alexander ¹ , Sinyakova Nadezhda ¹ , Kulikova Elizabeth ¹ , Khomenko Tatyana ² , Salakhutdinov Nariman ² , Kulikov Victor A. ^3,4 , Volcho Konstantin ²

Организации

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Fed Res Ctr, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Novosibirsk Inst Organ Chem, Siberian Branch, Ave Lavrentiev 9, Novosibirsk 630090, Russia
3	(Данные Web of science) Russian Acad Sci, Inst Automat & Electrometry, Siberian Branch, Novosibirsk 630090, Russia
4	(Данные Web of science) Skolkovo Inst Sci & Technol, Moscow, Russia

Background: Striatal-enriched Tyrosine Phosphatase (STEP) plays a key role in the mechanisms of neuronal signaling and is a potential molecular target for new generation of psychotropic drugs. STEP inhibitor, 8-(trifluoromethyl-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), shows anxiolytic effect on mice. Zebrafish (Danio rerio) is a suitable model for the study of anxiety pharmacology. Objective: The objective of this study is to investigate the effects of acute and chronic TC-2153 treatment on zebrafish anxiety-related behavior. Methods: The effects of acute (0.125 and 0.25 mg/l, 3 h) and chronic (0.125 mg/l, 14 days) administration of TC-2153 on locomotion and anxiety-related behavior (time spent near the bottom and mean distance from the bottom) of adult zebrafish in the Novel Tank (NT) test were compared with those of the same doses of fluoxetine chosen as a positive control. Results: Acute treatment with 0.125 mg/l and 0.25 mg/l of TC-2153 or fluoxetine decreased time spent near the bottom, increased time spent near the surface and increased mean distance from the bottom of tank. Chronic treatment with 0.125 mg/l of TC-2153 reduced only time spent near the tank bottom without any effect on time spent near the surface and mean distance from the bottom. while chronic administration of 0.125 mg/l of fluoxetine altered these three indices of anxiety. Conclusion: Both acute and chronic TC-2153 produces anxiety-like effect indicating STEP involved in the mechanism of anxiety-related behavior in zebrafish. At the same time, chronic treatment with TC-2153 reduced locomotor activity. Zebrafish is a promising laboratory object to study the role of STEP in the nervous system.

Kulikov A. , Sinyakova N. , Kulikova E. , Khomenko T. , Salakhutdinov N. , Kulikov V.A. , Volcho K.
Effects of Acute and Chronic Treatment of Novel Psychotropic Drug, 8-(Trifluoromethyl)-1, 2, 3, 4, 5-benzopentathiepin-6-amine Hydrochloride (TC-2153), on the Behavior of Zebrafish (Danio Rerio): A Comparison with Fluoxetine
Letters in Drug Design and Discovery. 2019. V.16. N12. P.1321-1328. DOI: 10.2174/1570180816666190221162952 WOS Scopus РИНЦ

Опубликована в печати:

8 нояб. 2019 г.

Web of science	WOS:000496232800002
Scopus	2-s2.0-85075164794
РИНЦ	41820208
OpenAlex	W2915862522