The effect of 3,7-diazabicyclo[3.3.1]nonanes containing monoterpenoid moieties on the physical activity of mice

The effect of 3,7-diazabicyclo[3.3.1]nonanes containing monoterpenoid moieties on the physical activity of mice Научная публикация

Журнал

Journal of Research in Pharmacy
ISSN: 2630-6344

Вых. Данные

Год: 2020, Том: 24, Номер: 2, Страницы: 196-204 Страниц : 9 DOI: 10.35333/jrp.2020.136

Ключевые слова

Actoprotectors; treadmill; bromantane; monoterpenoids; bispidine

Авторы

Kotlyarova Anastasiya A. ³ , Ponomarev Konstantin Yu ¹ , Morozova Ekaterina A. ¹ , Korchagina Dina, V ² , Suslov Evgeniy, V ¹ , Pavlova Alla, V ¹ , Tolstikova Tatyana G. ¹ , Volcho Konstantin P. ¹ , Salakhutdinov Nariman F. ¹

Организации

1	(Данные Web of science) Russian Acad Sci, Dept Med Chem, Novosibirsk Inst Organ Chem, Siberian Branch, Lavrentjev Av 9, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Dept Phys Organ Chem, Novosibirsk Inst Organ Chem, Siberian Branch, Lavrentjev Av 9, Novosibirsk 630090, Russia
3	(Данные Web of science) Russian Acad Sci, Dept Expt Pharmacol, Res Inst Clin & Expt Lymphol, Inst Cytol & Genet,Siberian Branch, Acad Timakova Str 2, Novosibirsk 630060, Russia

The aim of this work is to study the effect of agents combining fragments of monoterpenoids and 3,7-diazabicyclo[3.3.1]nonane (bispidine) on the performance of mice. Physical endurance was studied using two tests: exhaustive swimming with a load of 7% of body weight (after single dosing) and exhaustive treadmill running (after single dosing and a 7-day administration). It has been shown for the first time that derivatives of monoterpenoids with 3,7-diazabicyclo[3.3.1]nonane moiety containing methyl substituents at positions 1 and 5 have a stimulatory effect on the performance of mice, which exceeds the effect of the reference drug bromantane after single dosing. Compound K1-458, which contains (-)-myrtenal residues linked to a bispidine fragment via amino groups, is the most effective in increasing the duration of running and swimming at a dose of 100 mg/kg after single intragastric administration. It has been also established that the LD50 for these compounds exceeds 1,000 mg/kg.

Kotlyarova A.A. , Ponomarev K.Y. , Morozova E.A. , Korchagina D.V. , Suslov E.V. , Pavlova A.V. , Tolstikova T.G. , Volcho K.P. , Salakhutdinov N.F.
The effect of 3,7-diazabicyclo[3.3.1]nonanes containing monoterpenoid moieties on the physical activity of mice

Journal of Research in Pharmacy. 2020. V.24. N2. P.196-204. DOI: 10.35333/jrp.2020.136 WOS Scopus

Полный текст от издателя

Опубликована в печати:

12 мар. 2020 г.

Web of science	WOS:000520855700003
Scopus	2-s2.0-85085118551
OpenAlex	W3012226578