Application of Monoterpenoids and their Derivatives for Treatment of Neurodegenerative Disorders

Application of Monoterpenoids and their Derivatives for Treatment of Neurodegenerative Disorders Научная публикация

Журнал

Current Medicinal Chemistry
ISSN: 0929-8673 , E-ISSN: 1875-533X

Вых. Данные

Год: 2018, Том: 25, Номер: 39, Страницы: 5327-5346 Страниц : DOI: 10.2174/0929867324666170112101837

Ключевые слова

Acetylcholinesterase inhibitors; Alzheimer's disease; cannabinoids; Huntington's disease; monoterpenes; monoterpenoids; neuroprotective activity; Parkinson's disease

Авторы

Volcho Konstantin P. ^1,2 , Laev Sergey S. ¹ , Ashraf Ghulam Md ³ , Aliev Gjumrakch ^4,5,6,7 , Salakhutdinov Nariman F. ^1,2

Организации

1	(Данные Web of science) Russian Acad Sci, Siberian Div, Novosibirsk Inst Organ Chem, Prospect Akad Lavrenteva 9, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, St Pirogova 2, Novosibirsk 630090, Russia
3	(Данные Web of science) King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah, Saudi Arabia
4	(Данные Web of science) GALLY Int Biomed Res Consulting LLC, 7733 Louis Pasteur Dr,330, San Antonio, TX 78229 USA
5	(Данные Web of science) Univ Atlanta, Sch Hlth Sci & Healthcare Adm, E Johns Crossing 175, Johns Creek, GA 30097 USA
6	(Данные Web of science) Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka 142432, Russia
7	(Данные Web of science) Sechenov First Moscow State Med Univ, Moscow 119991, Russia

Neurodegenerative disorders (NDDs) like Alzheimer's disease, Parkinson's disease and Huntington's disease are a heterogeneous group of disorders with the progressive and severe loss of neurons. There are no full proof cures for these diseases, and only medicines are available that can alleviate some of the symptoms. Developing effective treatments for the NDDs is a difficult but necessary task. Hence, the investigation of monoterpenoids which modulate targets applicable to many NDDs is highly relevant. Many monoterpenoids have demonstrated promising neuroprotective activity mediated by various systems. It can form the basis for elaboration of agents which will be useful both for the alleviation of symptoms of NDDs and for the treatment of diseases progression and also for prevention of neurodegeneration. The further developments including detections of monoterpenoids and their derivatives with high neuroprotective or neurotrophic activity as well as the results of qualified clinical trials are needed to draw solid conclusions regarding the efficacy of these agents.

Volcho K.P. , Laev S.S. , Ashraf G.M. , Aliev G. , Salakhutdinov N.F.
Application of Monoterpenoids and their Derivatives for Treatment of Neurodegenerative Disorders
Current Medicinal Chemistry. 2018. V.25. N39. P.5327-5346. DOI: 10.2174/0929867324666170112101837 WOS Scopus РИНЦ

Опубликована в печати:

17 янв. 2019 г.

Web of science	WOS:000455988900008
Scopus	2-s2.0-85024861710
РИНЦ	38604643
OpenAlex	W2577926381