Реферат: A series of new heterocyclic compounds with the hexahydro-2H-chromene skeleton were prepared by reacting the monoterpenoid para-mentha-1,8-diene-5,6-diol with 4-alkyl-substituted aromatic aldehydes. Adding small alkyl substituents (methyl and ethyl) to the aldehyde aromatic ring increased the yields of hexahydrochromenes as compared with the analogous reaction with benzaldehyde. However, adding a branched substituent (isopropyl) and longer butyl and octyl moieties reduced the yields of the target compounds. The stereoselectivity of the reaction changed as the alkyl substituent lengthened. The analgesic activity of the obtained products was studied.

Библиографическая ссылка: Patrusheva O.S. , Pavlova A.V. , Korchagina D.V. , Tolstikova T.G. , Volcho K.P. , Salakhutdinov N.F.
Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2-Chromen-4,8-Diols Containing Alkyl-Substituted Aromatic Moieties
Chemistry of Natural Compounds. 2017. V.53. N6. P.1066-1071. DOI: 10.1007/s10600-017-2202-1 WOS Scopus РИНЦ

Даты:

Опубликована в печати:	1 нояб. 2017 г.
Опубликована online:	22 нояб. 2017 г.

Идентификаторы:

Web of science	WOS:000416801100012
Scopus	2-s2.0-85034632451
РИНЦ	35525686
OpenAlex	W2768591943

Альметрики: