Carrageenans-Sulfated Polysaccharides from Red Seaweeds as Matrices for the Inclusion of Echinochrome

Carrageenans-Sulfated Polysaccharides from Red Seaweeds as Matrices for the Inclusion of Echinochrome Научная публикация

Журнал

Marine Drugs
ISSN: 1660-3397

Вых. Данные

Год: 2017, Том: 15, Номер: 11, Номер статьи : 337, Страниц : DOI: 10.3390/md15110337

Ключевые слова

carrageenan; echinochrome; spectra; release; gastroprotective activity

Авторы

Yermak Irina M. ¹ , Mischchenko Natalia P. ¹ , Davydova Viktoria N. ¹ , Glazunov Valery P. ¹ , Tarbeeva Daria V. ¹ , Kravchenko Anna O. ¹ , Pimenova Evgeniya A. ² , Sorokina Irina V. ³

Организации

1	(Данные Web of science) Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, 100 Let Vladivostoku Prosp,159, Vladivostok 690022, Russia
2	(Данные Web of science) Russian Acad Sci, Far Eastern Branch, Natl Sci Ctr Marine Biol, Palchevskogo 17, Vladivostok 690041, Russia
3	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Lavrentjev Ave 9, Novosibirsk 630090, Russia

The possibility of using different types of carrageenans (CRG) as matrixes for incorporating of echinochrome A (Ech) was investigated. Ech interacts with carrageenans and is incorporated into the macromolecular structure of the polysaccharide. The inclusion of Ech in carrageenan matrices decreased its oxidative degradation and improved its solubility. The changing in the charge and morphology of CRGs during binding with Ech was observed. The rate of Ech release from CRG matrices depended on the structure of the used polysaccharide and the presence of specific ions. The gastroprotective effect of CRG/Ech complexes was investigated on the model of stomach ulcers induced by indomethacin in rats. Complexes of CRG/Ech exhibited significant gastroprotective activity that exceeded the activity of the reference drug Phosphalugel. The gastroprotective effect of the complexes can be associated with their protective layer on the surface of the mucous membrane of a stomach.

Yermak I.M. , Mischchenko N.P. , Davydova V.N. , Glazunov V.P. , Tarbeeva D.V. , Kravchenko A.O. , Pimenova E.A. , Sorokina I.V.
Carrageenans-Sulfated Polysaccharides from Red Seaweeds as Matrices for the Inclusion of Echinochrome

Marine Drugs. 2017. V.15. N11. 337 . DOI: 10.3390/md15110337 WOS Scopus РИНЦ

Полный текст от издателя

Опубликована online:

1 нояб. 2017 г.

Web of science	WOS:000416600200008
Scopus	2-s2.0-85036528926
РИНЦ	35511000
OpenAlex	W2766367919