Oxygen-Guided Radiation Therapy | Sciact

Oxygen-Guided Radiation Therapy Научная публикация

Журнал

International Journal of Radiation Oncology Biology Physics
ISSN: 0360-3016 , E-ISSN: 1879-355X

Вых. Данные

Год: 2019, Том: 103, Номер: 4, Страницы: 977-984 Страниц : 8 DOI: 10.1016/j.ijrobp.2018.10.041

Авторы

Epel Boris ^1,2 , Maggio Matthew C. ^1,2 , Barth Eugene D. ^1,2 , Miller Richard C. ^1,2 , Pelizzari Charles A. ^1,2 , Krzykawska-Serda Martyna ^1,2 , Sundramoorthy Subramanian, V ^1,2 , Aydogan Bulent ² , Weichselbaum Ralph R. ^1,2,3 , Tormyshev Victor M. ^1,4,5 , Halpern Howard J. ^1,2

Организации

1	(Данные Web of science) Univ Chicago, Natl Inst Hlth Ctr EPR Imaging Vivo Physiol, Chicago, IL 60637 USA
2	(Данные Web of science) Univ Chicago, Dept Radiat & Cellular Oncol, MC1105,5841 S Maryland Ave, Chicago, IL 60637 USA
3	(Данные Web of science) Univ Chicago, Ludwig Ctr Metastasis Res, Chicago, IL 60637 USA
4	(Данные Web of science) Novosibirsk Inst Organ Chem, Novosibirsk, Russia
5	(Данные Web of science) Novosibirsk State Univ, Novosibirsk, Russia

Purpose: It has been known for over 100 years that tumor hypoxia, a near-universal characteristic of solid tumors, decreases the curative effectiveness of radiation therapy. However, to date, there are no reports that demonstrate an improvement in radiation effectiveness in a mammalian tumor on the basis of tumor hypoxia localization and local hypoxia treatment. Methods and Materials: For radiation targeting of hypoxic subregions in mouse fibrosarcoma, we used oxygen images obtained using pulse electron paramagnetic resonance pO(2) imaging combined with 3D-printed radiation blocks. This achieved conformal radiation delivery to all hypoxic areas in FSa fibrosarcomas in mice. Results: We demonstrate that treatment delivering a radiation boost to hypoxic volumes has a significant (P = .04) doubling of tumor control relative to boosts to well-oxygenated volumes. Additional dose to well-oxygenated tumor regions minimally increases tumor control beyond the 15% control dose to the entire tumor. If we can identify portions of the tumor that are more resistant to radiation, it might be possible to reduce the dose to more sensitive tumor volumes without significant compromise in tumor control. Conclusions: This work demonstrates in a single, intact mammalian tumor type that tumor hypoxia is a local tumor phenomenon whose treatment can be enhanced by local radiation. Despite enormous clinical effort to overcome hypoxic radiation resistance, to our knowledge this is the first such demonstration, even in preclinical models, of targeting additional radiation to hypoxic tumor to improve the therapeutic ratio. (C) 2018 Elsevier Inc. All rights reserved.

Epel B. , Maggio M.C. , Barth E.D. , Miller R.C. , Pelizzari C.A. , Krzykawska-Serda M. , Sundramoorthy S.V. , Aydogan B. , Weichselbaum R.R. , Tormyshev V.M. , Halpern H.J.
Oxygen-Guided Radiation Therapy

International Journal of Radiation Oncology Biology Physics. 2019. V.103. N4. P.977-984. DOI: 10.1016/j.ijrobp.2018.10.041 WOS Scopus РИНЦ

Полный текст от издателя

Опубликована в печати:

1 мар. 2019 г.

Web of science	WOS:000459153600029
Scopus	2-s2.0-85059533908
РИНЦ	38699681
OpenAlex	W2899852478