Psychotropic effects of alkaloid lappaconitine and its various derivatives [Psikhotropnye svoistva alkaloida lappakonitina i ego nekotorykh proizvodnykh.]

Psychotropic effects of alkaloid lappaconitine and its various derivatives [Psikhotropnye svoistva alkaloida lappakonitina i ego nekotorykh proizvodnykh.] Научная публикация

Журнал

Экспериментальная и клиническая фармакология/Eksperimental'naya i Klinicheskaya Farmakologiya
ISSN: 0869-2092

Вых. Данные

Год: 2001, Том: 64, Номер: 4, Страницы: 7-9 Страниц : 3

Авторы

Tolstikova T.G. ¹ , Voevoda T.V. ¹ , Dolgikh M.P. ¹

Организации

1	(Scopus) Department of Natural and Biologically Active Compounds, Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akad. Lavrent'eva 9, Russia, Novosibirsk 630090, Russian Federation

The psychotropic activity of (I, base), its N-oxide, and a complex of the base with 18-alpha-H-glycyrrhizic acid (1:2) was studied. It was established that I and its N-oxide exhibit dopaminopositive effect whereas the complex produces a serotoninopositive effect. Toxicities of the lipophilic I is half that of the hydrophilic; toxicity of N-oxide and the complex are 60 and 100 times lower than the activity of lappaconitine (base).

Tolstikova T.G. , Voevoda T.V. , Dolgikh M.P.
Psychotropic effects of alkaloid lappaconitine and its various derivatives [Psikhotropnye svoistva alkaloida lappakonitina i ego nekotorykh proizvodnykh.]
Экспериментальная и клиническая фармакология/Eksperimental'naya i Klinicheskaya Farmakologiya. 2001. V.64. N4. P.7-9. Scopus РИНЦ

Scopus	2-s2.0-0035405705
РИНЦ	14960032