Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis

Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis Научная публикация

Журнал

Mendeleev Communications
ISSN: 0959-9436

Вых. Данные

Год: 2017, Том: 27, Номер: 5, Страницы: 439-442 Страниц : 4 DOI: 10.1016/j.mencom.2017.09.002

Авторы

Prima Darya O. ^1,2 , Vorontsova Elena V. ³ , Makarov Arkady G. ¹ , Makarov Alexander Yu. ¹ , Bagryanskaya Irina Yu. ^1,4 , Mikhailovskaya Tatiana F. ¹ , Slizhov Yuri G. ² , Zibarev Andrey V. ^1,2

Организации

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Tomsk State Univ, Dept Chem, Tomsk 634050, Russia
3	(Данные Web of science) Russian Acad Sci, Inst Mol Biol & Biophys, Siberian Branch, Novosibirsk 630117, Russia
4	(Данные Web of science) Novosibirsk State Univ, Dept Nat Sci, Novosibirsk 630090, Russia

The title compounds synthesized from halogenated arene-1,2-diamines revealed, together with the latter, cytotoxicity towards the Hep2 (laryngeal epidermoid carcinoma) cells. The cytotoxicity was high and was accompanied by pronounced apoptotic activity at low concentrations for fluorinated diazoles, triazoles and selenadiazoles.

Prima D.O. , Vorontsova E.V. , Makarov A.G. , Makarov A.Y. , Bagryanskaya I.Y. , Mikhailovskaya T.F. , Slizhov Y.G. , Zibarev A.V.
Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis
Mendeleev Communications. 2017. V.27. N5. P.439-442. DOI: 10.1016/j.mencom.2017.09.002 WOS Scopus РИНЦ

Опубликована в печати:

1 сент. 2017 г.

Web of science	WOS:000413618800002
Scopus	2-s2.0-85030125084
РИНЦ	31100771
OpenAlex	W2757424886