Combined inhibitory effect of sulfur-containing phenol SO-4 with natural and synthetic antioxidants in the oxidation of methyl oleate

Combined inhibitory effect of sulfur-containing phenol SO-4 with natural and synthetic antioxidants in the oxidation of methyl oleate Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Вых. Данные

Год: 2006, Том: 55, Номер: 8, Страницы: 1380-1387 Страниц : 8 DOI: 10.1007/s11172-006-0429-2

Ключевые слова

α-tocopherol; 3-hydroxypyridine derivatives; Mexidol; Phospholipids; Sulfur-containing antioxidants

Авторы

Perevozkina M.G. ¹ , Storozhok N.M. ¹ , Krysin A.P. ² , Borisenko V.E. ³

Организации

1	Tyumen State Medical Academy, 52 ul. Odesskaya, 625023, Tyumen, Russian Federation
2	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent’eva, 630090, Novosibirsk, Russian Federation
3	Tyumen State University, 10 ul. Semakova, 625003, Tyumen, Russian Federation

In a model system of initiated oxidation of methyl oleate, the antioxidant activities of 3-hydroxy-2-ethyl-6-methylpyridinesuccinate (mexidol) and bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl] disulfide (SO-4) were studied and compared with those of α-tocopherol and 1-hydroxy-2,6-di-tert-butyl-4- methylbenzene (dibunol). A linear pattern of dependence of the inhibitory effect on the concentration of compounds was established. The ability of antioxidants to decompose hydroperoxides and inhibit their accumulation was revealed. The combined inhibitory effects of SO-4 with mexidol, α-tocopherol, and phospholipids were described for the first time. The rate constant for disproportionation of the SO-4 phenoxyl radicals, k 9 = 0.90.10 3 L mol-1 s-1, was determined by steady-state photolysis. The rate constant k 10 eff for the reactions of SO-4 phenoxyl radicals with lipids characterized by different unsaturation degrees were determined for methyl oleate, linolic and arachidonic acids containing one, two, and four multiple bonds, and phospholiopids containing polyunsaturated fatty acids. © 2006 Springer Science+Business Media, Inc.

Perevozkina M.G. , Storozhok N.M. , Krysin A.P. , Borisenko V.E.
Combined inhibitory effect of sulfur-containing phenol SO-4 with natural and synthetic antioxidants in the oxidation of methyl oleate
Russian Chemical Bulletin. 2006. V.55. N8. P.1380-1387. DOI: 10.1007/s11172-006-0429-2 WOS Scopus РИНЦ

Опубликована в печати:

1 авг. 2006 г.

Web of science	WOS:000243827500010
Scopus	2-s2.0-33845926148
РИНЦ	13530937
OpenAlex	W1968885811