Anti-influenza activity of monoterpene-containing substituted coumarins

Anti-influenza activity of monoterpene-containing substituted coumarins Научная публикация

Журнал

Bioorganic and Medicinal Chemistry Letters
ISSN: 0960-894X , E-ISSN: 1464-3405

Вых. Данные

Год: 2017, Том: 27, Номер: 13, Страницы: 2920-2925 Страниц : 6 DOI: 10.1016/j.bmcl.2017.04.091

Ключевые слова

Terpene; Coumarin; Anti-influenza activity; Antivirals; Cytotoxicity; Influenza A virus; Aurapten; Myrtenal

Авторы

Khomenko Tatyana M. ^1,3 , Zarubaev Vladimir V. ² , Orshanskaya Iana R. ² , Kadyrova Renata A. ² , Sannikova Victoria A. ^1,3 , Korchagina Dina V. ¹ , Volcho Konstantin P. ^1,3 , Salakhutdinov Nariman F. ^1,3

Организации

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2	(Данные Web of science) Influenza Res Inst, Dept Chemotherapy, 15-17 Prof Popova St, St Petersburg 197376, Russia
3	(Данные Web of science) Novosibirsk State Univ, Pirogova 2, Novosibirsk 630090, Russia

Compounds simultaneously carrying the monoterpene and coumarin moieties have been tested for cytotoxicity and inhibition of activity against influenza virus A/California/07/09 (H1N1) pdm09. The structure of substituents in the coumarin framework, as well as the structure and the absolute configuration of the monoterpenoid moiety, are shown to significantly influence the anti-influenza activity and cytotoxicity of the compounds under study. The compounds with a bicyclic pinane framework exhibit the highest selectivity indices (the ratios between the cytotoxicity and the active dose). The derivative of (-)-myrtenol 15c, which is characterized by promising activity, low cytotoxicity, and synthetic accessibility, has the greatest potential among this group of compounds. It exhibited the highest activity when added to the infected cell culture at early stages of viral reproduction. (C) 2017 Elsevier Ltd. All rights reserved.

Khomenko T.M. , Zarubaev V.V. , Orshanskaya I.R. , Kadyrova R.A. , Sannikova V.A. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F.
Anti-influenza activity of monoterpene-containing substituted coumarins
Bioorganic and Medicinal Chemistry Letters. 2017. V.27. N13. P.2920-2925. DOI: 10.1016/j.bmcl.2017.04.091 WOS Scopus РИНЦ

Опубликована в печати:

1 июл. 2017 г.

Web of science	WOS:000402470600016
Scopus	2-s2.0-85019144448
РИНЦ	31026555
OpenAlex	W2607788412