Improvement of pharmacological values of the nifedipine by means of mechanochemical complexation with glycyrrhizic acid

Improvement of pharmacological values of the nifedipine by means of mechanochemical complexation with glycyrrhizic acid Научная публикация

Журнал

Biomeditsinskaya Khimiya
ISSN: 2310-6905

Вых. Данные

Год: 2010, Том: 56, Номер: 2, Страницы: 187-194 Страниц : DOI: 10.18097/pbmc20105602187

Ключевые слова

Complexation; Glycosides; Glycyrrhizic acid; Nifedipine

Авторы

Tolstikova T. G. , Khvostov M. V. , Bryzgalov A. O. , Dushkin A. V. , Meteleva E. S.

Организации

1	(Scopus) Novosibirsk Institute of Organic Chemistry, Siberian Branch of RAS, Acad. Lavrentjev Ave. 9, Novosibirsk, 630090, Russian Federation
2	(Scopus) Institute of Solid State Chemistry and Mechanochemistiy, Siberian Branch of RAS, Novosibirsk, Russian Federation

A new water-soluble form of the calcium blocker nifedipine (NF) with glycyrrtrizic acid (GA) (with molecular ratio 1:4) has been obtained by mechanochemical synthesis. Its pharmacological advantages in comparison with nifedipine were determined. An effective dose of nifedipine in complex reduced to 10 times as compared to its therapeutic dose while high antihypertensive activity preservation and pleiotropic antiarhythmic activity enhancement. This new antihypertensive and antiarhythmic agent (complex of NF:GA = 1:4) is chemically stable and safe for parenteral administration.

Tolstikova T.G. , Khvostov M.V. , Bryzgalov A.O. , Dushkin A.V. , Meteleva E.S.
Improvement of pharmacological values of the nifedipine by means of mechanochemical complexation with glycyrrhizic acid

Biomeditsinskaya Khimiya. 2010. V.56. N2. P.187-194. DOI: 10.18097/pbmc20105602187 Scopus

Полный текст от издателя

Опубликована в печати:

1 мар. 2010 г.

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