Pharmacokinetic alterations of warfarin in its clathrate with arabinogalactan

Pharmacokinetic alterations of warfarin in its clathrate with arabinogalactan Научная публикация

Журнал

Asian Journal of Pharmaceutical and Clinical Research
ISSN: 0974-2441

Вых. Данные

Год: 2012, Том: 5, Номер: SUPPL.4, Страницы: 251-252 Страниц : 2

Ключевые слова

Arabinogalactan; Clathrate; Pharmacokinetics; Rats; Warfarin

Авторы

Khvostov M.V. ¹ , Tolstikova T.G. ¹ , Chernonosov A.A. ¹ , Fedorova O.S. ² , Lifshits G.I. ²

Организации

1	(Scopus) N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry the Siberian Branch, Russian Academy of Sciences, Acad. Lavrentiev Ave., 9, 630090 Novosibirsk, Russian Federation
2	(Scopus) Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentjev Ave., 8, 630090 Novosibirsk, Russian Federation

Pharmacokinetic parameters of warfarin (WF) in its clathrate with arabinogalactan (AG) were investigated after oral administration at a dose of 20 mg/kg. The concentrations of warfarin in rat plasma were analyzed by the MS/MS method. Noncompartmental analysis was used for calculation of pharmacokinetic parameters: clearance (CL), mean residence time (MRT), T1/2 and AUC. It was found that Cmax of WF was achieved for 7 hours faster (Tmax) then such of WF in the clathrate with AG and clearance value of clathrated WF is greater than for blank WF (1.52±0.03 vs 1.93±0.18 ml/h).

Khvostov M.V. , Tolstikova T.G. , Chernonosov A.A. , Fedorova O.S. , Lifshits G.I.
Pharmacokinetic alterations of warfarin in its clathrate with arabinogalactan
Asian Journal of Pharmaceutical and Clinical Research. 2012. V.5. NSUPPL.4. P.251-252. Scopus РИНЦ

Scopus	2-s2.0-84874674317
РИНЦ	20485452