Effect of microwave irradiation on arabinogalactan and its interaction with betulin diacetate

Effect of microwave irradiation on arabinogalactan and its interaction with betulin diacetate Научная публикация

Журнал

Химия растительного сырья
ISSN: 1029-5151 , E-ISSN: 1029-5143

Вых. Данные

Год: 2017, Номер: 4, Страницы: 73-79 Страниц : 7 DOI: 10.14258/jcprm.2017041854

Ключевые слова

Arabinogalactan; Betulin diacetate; Complexation; Microwave irradiation; Solubility

Авторы

Malyar Yu.N. ^1,2 , Mikhailenko M.A. ³ , Pankrushina N.A. ⁴ , Mikheev A.N. ⁵ , Kuznetsova S.A. ^1,2 , Shakhtshneider T.P. ^3,5

Организации

1	(Scopus) Institute of Chemistry and Chemical Technology, SB RAS, FRC KSC SB RAS, Akademgorodok, 50-24, Krasnoyarsk, 660036, Russian Federation
2	(Scopus) Siberian Federal University, pr Svobodny, 79, Krasnoyarsk, 660041, Russian Federation
3	(Scopus) Institute of Solid State Chemistry and Mechanochemistry, SB RAS, ul. Kutateladze, 18, Novosibirsk, 630128, Russian Federation
4	(Scopus) N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, pr. Lavrentieva, 9, Novosibirsk, 630090, Russian Federation
5	(Scopus) Novosibirsk State University, ul. Pirogova, 2, Novosibirsk, 630090, Russian Federation

Betulin diacetate (BDA) has a variety of biological activities, but poor solubility in water limits its application. The use of arabinogalactan (AG) as a complexing agent is a promising method for solving the problem of solubilization of drugs. In this work, influence of microwave (MW) irradiation on the properties of AG and BDA and their interaction in the aqueous suspension with formation of a water-soluble supramolecular complex was studied. It is shown that the MW heating of AG under hard conditions can lead to degradation of the biopolymer. The use of MW heating allowed significantly reducing the complex preparation time compared to the conventional synthesis in a water bath. The preliminary mechanical treatment of the mixture of components, leading to the formation of mechanocomposites, inhibited the reaction between the components in the aqueous suspension under MW irradiation. The IR spectroscopy method has shown that a supramolecular complex formed under MW irradiation similar to that formed by conventional heating. BDA-AG complex was isolated from a MW heated solution as a thin film, which may be a promising material for pharmaceutical applications.

Malyar Y.N. , Mikhailenko M.A. , Pankrushina N.A. , Mikheev A.N. , Kuznetsova S.A. , Shakhtshneider T.P.
Effect of microwave irradiation on arabinogalactan and its interaction with betulin diacetate

Химия растительного сырья. 2017. N4. P.73-79. DOI: 10.14258/jcprm.2017041854 Scopus РИНЦ

Полный текст от издателя

Опубликована online:

31 мая 2017 г.

Scopus	2-s2.0-85041634449
РИНЦ	30755072
OpenAlex	W2778734398