Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells [Апоптоз как основной механизм цитотоксического действия урсоловой и помоловой кислот в клетках глиомы]

Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells [Апоптоз как основной механизм цитотоксического действия урсоловой и помоловой кислот в клетках глиомы] Научная публикация

Журнал

Молекулярная биология (Molecularnaya biologiya)
ISSN: 0026-8984

Вых. Данные

Год: 2017, Том: 51, Номер: 5, Страницы: 809-816 Страниц : 8 DOI: 10.7868/S002689841705007X

Ключевые слова

apoptosis; glioma; pomolic acid; selective cytotoxicity; ursolic acid

Авторы

Frolova T.S. ² , Фролова Т. С. , Lipeeva A.V. ¹ , Липеева А. В. , Baev D.S. ¹ , Баев Д. С. , Tsepilov Y.A. ^2,3 , Цепилов Я. А. , Синицына О. И. , Sinitsyna O.I. ²

Организации

1	(Scopus) Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090 Russia
2	(Scopus) Institute of Cytology and GeneticsSiberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090 Russia
3	(Scopus) Novosibirsk State University, Novosibirsk, 630090 Russia

Pentacyclic triterpene acids are of great interest as compounds that exhibit selective cytotoxicity against malignant tumor cells. If earlier studies were carried out mainly in cancer cells of epithelial origin, in the present work the cytotoxic effect of ursolic and pomolic acids on the primary and permanent glioma cell lines was analyzed. Both compounds are toxic to oncotransformed cells and induce apoptosis in U-87 MG line. Using molecular docking, it has been shown that Akt1 and MDM2 may be potential targets of the studied triterpene acids. It has been suggested that ursolic and pomolic acids induce apoptosis in glioma cells through inhibition of the PI3K/Akt signaling pathway, and they can be considered as potentially promising agents for the treatment of glioblastoma.

Frolova T.S. , Фролова Т.С. , Lipeeva A.V. , Липеева А.В. , Baev D.S. , Баев Д.С. , Tsepilov Y.A. , Цепилов Я.А. , Синицына О.И. , Sinitsyna O.I.
Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells [Апоптоз как основной механизм цитотоксического действия урсоловой и помоловой кислот в клетках глиомы]
Молекулярная биология (Molecularnaya biologiya). 2017. Т.51. №5. С.809-816. DOI: 10.7868/S002689841705007X Scopus РИНЦ

Scopus	2-s2.0-85049071614
РИНЦ	29959235
OpenAlex	W2804075587