Oxygen-induced leakage of spin polarization in Overhauser-enhanced magnetic resonance imaging: Application for oximetry in tumors

Oxygen-induced leakage of spin polarization in Overhauser-enhanced magnetic resonance imaging: Application for oximetry in tumors Научная публикация

Журнал

Journal of Magnetic Resonance
ISSN: 1090-7807

Вых. Данные

Год: 2018, Том: 297, Страницы: 42-50 Страниц : 9 DOI: 10.1016/j.jmr.2018.10.005

Ключевые слова

Leakage of spin polarization; Overhauser-enhanced magnetic resonance imaging (OMRI); Oximetry; Proton-electron double-resonance imaging (PEDRI); Trityl radical; Tumor tissue oximetry

Авторы

Gorodetskii A.A. ^1,2,3,4 , Eubank T.D. ^1,5,6 , Driesschaert B. ^1,6,7 , Poncelet M. ^1,2 , Ellis E. ⁵ , Khramtsov V.V. ^1,2,6 , Bobko A.A. ^1,2,6

Организации

1	(Scopus) In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, United States
2	(Scopus) Department of Biochemistry, West Virginia University, School of Medicine, Morgantown, WV 26506, United States
3	(Scopus) N.N. Voroztsov, Novosibirsk Institute of Organic Chemistry SB RAS, Novosibirsk, 630090, Russian Federation
4	(Scopus) Novosibirsk State University, Novosibirsk, 630090, Russian Federation
5	(Scopus) Department of Microbiology, Immunology & Cell Biology, West Virginia University, School of Medicine, Morgantown, WV 26506, United States
6	(Scopus) Department of Pharmaceutical Sciences, West Virginia University, School of Pharmacy, Morgantown, WV 26506, United States
7	(Scopus) West Virginia University Cancer Institute, Morgantown, WV 26506, United States

Overhauser-enhanced Magnetic Resonance Imaging (OMRI) is a double resonance technique applied for oxygen imaging in aqueous samples and biological tissues. In this report, we present an improved OMRI approach of oxygen measurement using the single line “Finland” trityl spin probe. Compared to a traditional approach, we introduced an additional mechanism of leakage of spin polarization due to an interaction of a spin system with oxygen. The experimental comparison of the new approach with an oxygen-dependent leakage factor to a traditional approach performed in phantom samples in vitro, and mouse tumor model in vivo, shows improved accuracy of determination of oxygen and contrast agent concentrations. © 2018 Elsevier Inc.

Gorodetskii A.A. , Eubank T.D. , Driesschaert B. , Poncelet M. , Ellis E. , Khramtsov V.V. , Bobko A.A.
Oxygen-induced leakage of spin polarization in Overhauser-enhanced magnetic resonance imaging: Application for oximetry in tumors

Journal of Magnetic Resonance. 2018. V.297. P.42-50. DOI: 10.1016/j.jmr.2018.10.005 WOS Scopus РИНЦ

Полный текст от издателя

Опубликована в печати:

1 дек. 2018 г.

Web of science	WOS:000453112500006
Scopus	2-s2.0-85055210775
РИНЦ	38644739
OpenAlex	W2895996507