New type of anti-influenza agents based on benzo[d][1,3]dithiol core

New type of anti-influenza agents based on benzo[d][1,3]dithiol core Научная публикация

Журнал

Bioorganic and Medicinal Chemistry Letters
ISSN: 0960-894X , E-ISSN: 1464-3405

Вых. Данные

Год: 2020, Том: 30, Номер: 24, Номер статьи : 127653, Страниц : DOI: 10.1016/j.bmcl.2020.127653

Ключевые слова

Antiviral activity; Benzodithiols; H1N1 influenza virus; Hemagglutinin; Heterocyclic compounds; M2 channel

Авторы

Khomenko T.M. ¹ , Zarubaev V.V. ² , Kireeva Marina V. ³ , Volobueva A.S. ² , Slita A.V. ² , Borisevich S.S. ⁴ , Korchagina D.V. ¹ , Komarova N.I. ¹ , Volcho K.P. ¹ , Salakhutdinov N.F. ¹

Организации

1	(Scopus) Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation
2	(Scopus) Department of Virology, Pasteur Institute of Epidemiology and Microbiology, 14 Mira St., 197101, St. Petersburg, Russian Federation
3	(Scopus) Saint Petersburg State University, 7/9 Universitetskaya nab.,199034, St. Petersburg, Russian Federation
4	(Scopus) Ufa Institute of Chemistry Ufa Federal Research Center RAS, pr. Oktyabrya, 71, Ufa, 450054, Russian Federation

We synthesized a series of amides with a benzo[d][1,3]dithiol core. The chemical library of compounds was tested for their cytotoxicity and inhibiting activity against influenza virus A/California/07/09 (H1N1)pdm09 in MDCK cells. For each compound, values of CC50, IC50 and selectivity index (SI) were determined. Compounds of this structure type were for the first time found to exhibit anti-influenza activity. The structure of an amide substituent in the tested compounds was demonstrated to have a significant effect on their activity against the H1N1 influenza virus and cytotoxicity. Compound 4d has a high selectivity index of about 30. 4d was shown to be most potent at early stages of viral cycle. In direct fusogenic assay it demonstrated dose-dependent activity against fusogenic activity of hemagglutinin of influenza virus. Based on molecular docking and regression analysis data, viral hemagglutinin was suggested as possible target for these new antiviral agents. © 2020 Elsevier Ltd

Khomenko T.M. , Zarubaev V.V. , Kireeva M.V. , Volobueva A.S. , Slita A.V. , Borisevich S.S. , Korchagina D.V. , Komarova N.I. , Volcho K.P. , Salakhutdinov N.F.
New type of anti-influenza agents based on benzo[d][1,3]dithiol core
Bioorganic and Medicinal Chemistry Letters. 2020. V.30. N24. 127653 . DOI: 10.1016/j.bmcl.2020.127653 WOS Scopus РИНЦ РИНЦ

Опубликована в печати:

1 дек. 2020 г.

Web of science	WOS:000595005000007
Scopus	2-s2.0-85094903948
РИНЦ	44403540 , 45178734
OpenAlex	W3096655816