New reaction products of acetylacetone with semicarbazide derivatives

New reaction products of acetylacetone with semicarbazide derivatives Научная публикация

Журнал

ACS Omega
, E-ISSN: 2470-1343

Вых. Данные

Год: 2021, Том: 6, Номер: 12, Страницы: 8637-8645 Страниц : 9 DOI: 10.1021/acsomega.1c00518

Авторы

Glukhacheva Vera S. ¹ , Il'Yasov Sergey G. ¹ , Kazantsev Igor V. ¹ , Shestakova Elena O. ¹ , Il'Yasov Dmitri S. ¹ , Eltsov Ilia V. ² , Nefedov Andrey A. ^2,3 , Gatilov Yuri V. ³

Организации

1	Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences (IPCET SB RAS), Biysk, 659322, Russian Federation
2	Novosibirsk State University, Novosibirsk, 630090, Russian Federation
3	Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences (NIOCh SB RAS), Novosibirsk, 630090, Russian Federation

A new approach is suggested herein for the synthesis of pyrazole derivatives by reacting 4-nitrosemicarbazide with acetylacetone. Additional studies were done on the reaction of acetylacetone with semicarbazide and its derivatives (4-aminosemicarbazide, methylsemicarbazide, and dimethylsemicarbazide). The study on the reaction with acetylacetone resulted in monocyclic 3, 5-dimethyl-N-nitropyrazole-1-carboxamide, monocyclic 5-hydroxy-3, 5-dimethyl-2-pyrazoline, and bicyclic bis(3, 5- dimethylpyrazole-1-carbonyl)hydrazine, and conditions for the formation of acetone semicarbazone were identified. The structures of the resultant compounds were validated by physicochemical analytical methods, including X-ray diffraction. The computer-aided screening in the PASS prediction software discovered a high biological activity of the newly obtained compounds. © XXXX The Authors.

Glukhacheva V.S. , Il'Yasov S.G. , Kazantsev I.V. , Shestakova E.O. , Il'Yasov D.S. , Eltsov I.V. , Nefedov A.A. , Gatilov Y.V.
New reaction products of acetylacetone with semicarbazide derivatives

ACS Omega. 2021. V.6. N12. P.8637-8645. DOI: 10.1021/acsomega.1c00518 WOS Scopus

Полный текст от издателя

Опубликована online:	17 мар. 2021 г.
Опубликована в печати:	30 мар. 2021 г.

Web of science	WOS:000636600000072
Scopus	2-s2.0-85103790709
OpenAlex	W3137593184