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Synthesis and antiviral activity of novel 3-substituted pyrazolinium salts Научная публикация

Журнал Chemistry of Heterocyclic Compounds
ISSN: 0009-3122 , E-ISSN: 1573-8353
Вых. Данные Год: 2021, Том: 57, Номер: 4, Страницы: 432-441 Страниц : 10 DOI: 10.1007/s10593-021-02921-7
Ключевые слова 2-pyrazoline; adamantanone; antiviral activity; camphor; camphorquinone; carvone; influenza A (H1N1) virus; myrtenal; norcamphor
Авторы Vorozhtsov Nikolai O. 1 , Yarovaya Olga I. 2 , Roznyatovskii Vitalii A. 1 , Tarasevich Boris N. 1 , Kozlovskaya Yuliya A. 1 , Petkova Aneliya I. 1 , Slita Aleksander V. 3 , Sinegubova Ekaterina O. 3 , Zarubaev Vladimir V. 3 , Salakhutdinov Nariman F. 2 , Beloglazkina Elena K. 1
Организации
1 Lomonosov Moscow State University, 1, Build. 3 Leninskie Gory, Moscow, 119991, Russian Federation
2 N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk, 630090, Russian Federation
3 Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St., Saint Petersburg, 197101, Russian Federation

Реферат: [Figure not available: see fulltext.] For the first time, convenient methods for the preparation of pyrazoline N-alkylidene salts based on terpene (camphor, camphorquinone, carvone) ketones, cage (adamantanone and norcamphor) ketones, and natural aldehydes (carvone and myrtenal) allowing the isolation of stable pyrazolinium salts in individual form were proposed. Optimization of the conditions for the synthesis of the target products was carried out. The antiviral activity of the synthesized salts was studied; among the tested compounds 1-bornylidene-3-phenylpyrazolinium tetrafluoroborate (IC50 6.2 μM, SI 107) exhibited the greatest activity against influenza A/Puerto Rico/8/34 (H1N1) virus. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.
Библиографическая ссылка: Vorozhtsov N.O. , Yarovaya O.I. , Roznyatovskii V.A. , Tarasevich B.N. , Kozlovskaya Y.A. , Petkova A.I. , Slita A.V. , Sinegubova E.O. , Zarubaev V.V. , Salakhutdinov N.F. , Beloglazkina E.K.
Synthesis and antiviral activity of novel 3-substituted pyrazolinium salts
Chemistry of Heterocyclic Compounds. 2021. V.57. N4. P.432-441. DOI: 10.1007/s10593-021-02921-7 WOS Scopus РИНЦ
Даты:
Опубликована в печати: 1 апр. 2021 г.
Опубликована online: 14 мая 2021 г.
Идентификаторы:
Web of science WOS:000650093200005
Scopus 2-s2.0-85105909229
РИНЦ 46065586
OpenAlex W3162782564
Альметрики: