The effect of adding modified chitosan on the strength properties of bacterial cellulose for clinical applications

The effect of adding modified chitosan on the strength properties of bacterial cellulose for clinical applications Научная публикация

Журнал

Polymers
ISSN: 2073-4360

Вых. Данные

Год: 2021, Том: 13, Номер: 12, Номер статьи : 1995, Страниц : DOI: 10.3390/polym13121995

Ключевые слова

Bacterial nanocellulose; Chitosan gel; Dura matter; Dura substitutes; Factor analysis; Novochizol™; Tissue biomechanics; Vancomycin

Авторы

Lipovka A. ¹ , Kharchenko A. ² , Dubovoy A. ^1,3 , Filipenko M. ⁴ , Stupak V. ² , Mayorov A. ⁵ , Fomenko V. ⁶ , Geydt P. ⁷ , Parshin D. ¹

Организации

1	Lavrentyev Institute of Hydrodynamics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation
2	Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan, Novosibirsk, 630090, Russian Federation
3	Federal Neurosurgical Center, Novosibirsk, 630048, Russian Federation
4	Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation
5	Institute of Laser Physics of the Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation
6	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation
7	Novosibirsk State University, Novosibirsk, 630090, Russian Federation

Currently, several materials for the closure of the dura mater (DM) defects are known. However, the long-term results of their usage reveal a number of disadvantages. The use of antibiotics and chitosan is one of the major trends in solving the problems associated with infectious after-operational complications. This work compares the mechanical properties of samples of bacterial nanocellulose (BNC) impregnated with Novochizol™ and vancomycin with native BNC and preserved and native human DM. An assessment of the possibility of controling the mechanical properties of these materials by changing their thickness has been performed by statistical analysis methods. A total of 80 specimens of comparable samples were investigated. During the analysis, the results obtained, the factor of Novochizol™ addition has provided a statistically significant impact on the strength properties (Fisher Criteria p-value 0.00509 for stress and 0.00112 for deformation). Moreover, a stronger relationship between the thickness of the samples and their ultimate load was shown: R2=0.236 for BNC + Novochizol™ + vancomycin, compared to R2=0.0405 for native BNC. Using factor analysis, it was possible to show a significant effect of modified chitosan (Novochizol™) on the ultimate stress (p-value = 0.005). © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Lipovka A. , Kharchenko A. , Dubovoy A. , Filipenko M. , Stupak V. , Mayorov A. , Fomenko V. , Geydt P. , Parshin D.
The effect of adding modified chitosan on the strength properties of bacterial cellulose for clinical applications

Polymers. 2021. V.13. N12. 1995 . DOI: 10.3390/polym13121995 WOS Scopus

Полный текст от издателя

Опубликована online:

18 июн. 2021 г.

Web of science	WOS:000666382900001
Scopus	2-s2.0-85108682491
OpenAlex	W3174765173