Chemical approach to the design of effective antidiabetic agents

Chemical approach to the design of effective antidiabetic agents Научная публикация

Журнал

Russian Chemical Reviews
ISSN: 0036-021X , E-ISSN: 1468-4837

Вых. Данные

Год: 2016, Том: 85, Номер: 12, Страницы: 1313-1337 Страниц : 25 DOI: 10.1070/RCR4624

Авторы

Rogachev Artem D. ^1,2 , Kuranov Sergey O. ¹ , Salakhutdinov Nariman F. ^1,2

Организации

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Prosp Akad Lavrentieva 9, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Ul Pirogova 2, Novosibirsk 630090, Russia

The review discusses the literature data on the structures of hypoglycemic compounds with different mechanisms of action. It is shown that many drugs acting on different biological targets have similar or identical structural moieties. Compounds containing a sulfonyl group, a 3-phenylpropanoic acid moiety or the indane ring, as well as derivatives of heterocyclic systems (quinoline, isoquinoline, benzoxazine, thiazolidine and so on) are presented. The approach to the design of multi target hypoglycemic drugs by combining different pharmacophoric groups in one molecule is considered. The prospects of the use of these agents for the treatment of type 2 diabetes are discussed. The bibliography includes 177 references.

Rogachev A.D. , Kuranov S.O. , Salakhutdinov N.F.
Chemical approach to the design of effective antidiabetic agents
Russian Chemical Reviews. 2016. V.85. N12. P.1313-1337. DOI: 10.1070/RCR4624 WOS Scopus РИНЦ

Рогачев А.Д. , Куранов С.О. , Салахутдинов Н.Ф.
Химический подход к разработке эффективных противодиабетических препаратов
Успехи химии/Uspekhi Khimii. 2016. Т.85. №12. С.1313-1337. DOI: 10.1070/RCR4624?locatt=labelRUSSIAN РИНЦ

Опубликована online:	20 дек. 2016 г.
Опубликована в печати:	31 дек. 2016 г.

Web of science	WOS:000391302600003
Scopus	2-s2.0-85007475087
РИНЦ	32803839
OpenAlex	W2332714892