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Compounds Combining Aminoadamantane and Monoterpene Moieties: Cytotoxicity and Mutagenic Effects Научная публикация

Журнал Medicinal Chemistry
ISSN: 1573-4064 , E-ISSN: 1875-6638
Вых. Данные Год: 2015, Том: 11, Номер: 7, Страницы: 629-635 Страниц : DOI: 10.2174/1573406411666150518110053
Ключевые слова Adamantane; amine; anticancer activity; cytotoxicity; genotoxicity; monoterpene
Авторы Suslov Evgeniy V. 1 , Ponomarev Konstantin Yu. 1 , Rogachev Artem D. 1,2 , Pokrovsky Michail A. 2 , Pokrovsky Andrey G. 2 , Pykhtina Maria B. 3 , Beklemishev Anatoly B. 3 , Korchagina Dina V. 1 , Volcho Konstantin P. 1,2 , Salakhutdinov Nariman F. 1,2
Организации
1 (Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2 (Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
3 (Данные Web of science) Russian Acad Med Sci, Siberian Branch, Res Inst Biochem, Novosibirsk, Russia

Реферат: A series of secondary amines combining monoterpenoid and aminoadamantane moieties have been synthesized. Their cytotoxic activity against human cancer cells CEM-13, MT-4, and U-937 has been studied for the first time. Most of the obtained compounds exhibited a significant cytotoxic activity with the median cytotoxic dose (CTD50) ranging from 6 to 84 mu M. The most promising results were obtained for compound 2b which was synthesized from 1-aminoadamantane and (-)-myrtenal and revealed a high activity against all tumor lines used (CTD50 = 12 divided by 21 mu M) along with low toxicity with respect to MDCK cells (CTD50 = 1500 mu M). The synthesized amines do not exert the genotoxic effect on cells of the biosensor strain based on recombinant E. coli cells bearing the pRAC-gfp plasmid.
Библиографическая ссылка: Suslov E.V. , Ponomarev K.Y. , Rogachev A.D. , Pokrovsky M.A. , Pokrovsky A.G. , Pykhtina M.B. , Beklemishev A.B. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F.
Compounds Combining Aminoadamantane and Monoterpene Moieties: Cytotoxicity and Mutagenic Effects
Medicinal Chemistry. 2015. V.11. N7. P.629-635. DOI: 10.2174/1573406411666150518110053 WOS Scopus РИНЦ
Даты:
Опубликована в печати: 22 сент. 2015 г.
Идентификаторы:
Web of science WOS:000361825400004
Scopus 2-s2.0-84945469369
РИНЦ 24967568
OpenAlex W2224258569
Альметрики: