Abstract: Toxic liver injury with the development of fi brosis and cirrhosis was modeled in Wistar rats by intragastric administration of 0.1 ml/kg CCl4 in combination with 5% ethanol with glucose 3 times a week for 6 weeks. The animals were treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It was found that betulonic acid amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, which was accompanied by a signifi cant decrease in the severity of liver fi brosis and the absence of cirrhotic transformation of the liver.

Cite: Semenov D.E. , Zhukova N.A. , Ivanova E.P. , Sorokina I.V. , Baiev D.S. , Nepomnyashchikh G.I. , Tolstikova T.G. , Biryukova M.S.
Hepatoprotective Properties of Betulonic Acid Amide and Heptral in Toxic Liver Injury Induced by Carbon Tetrachloride in Combination with Ethanol
Bulletin of Experimental Biology and Medicine. 2015. V.158. N3. P.336-341. DOI: 10.1007/s10517-015-2756-5 WOS Scopus РИНЦ

ArticleLinkType.TRANSLATED_TO_ORIGINAL: Семенов Д.Е. , Жукова Н.А. , Иванова Е.П. , Сорокина И.В. , Баев Д.С. , Непомнящих Г.И. , Толстикова Т.Г. , Борисова М.С.
Гепатопротекторные свойства амида бетулоновой кислоты и гептрала при токсическом поражении печени тетрахлорметаном в сочетании с этанолом
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2014. Т.158. №9. С.320-326. РИНЦ

Dates:

Published print:	Jan 1, 2015
Published online:	Jan 9, 2015

Identifiers:

Web of science	WOS:000348209300014
Scopus	2-s2.0-84939996122
Elibrary	24939068
OpenAlex	W2082470462

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