Hepatoprotective Properties of Betulonic Acid Amide and Heptral in Toxic Liver Injury Induced by Carbon Tetrachloride in Combination with Ethanol

Hepatoprotective Properties of Betulonic Acid Amide and Heptral in Toxic Liver Injury Induced by Carbon Tetrachloride in Combination with Ethanol Научная публикация

Журнал

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Вых. Данные

Год: 2015, Том: 158, Номер: 3, Страницы: 336-341 Страниц : 6 DOI: 10.1007/s10517-015-2756-5

Ключевые слова

toxic liver injury; cirrhosis; cytoprotection; carbon tetrachloride; betulonic acid amide

Авторы

Semenov D.E. ² , Zhukova N.A. ¹ , Ivanova E.P. ¹ , Sorokina I.V. ¹ , Baiev D.S. ¹ , Nepomnyashchikh G.I. ² , Tolstikova T.G. ¹ , Biryukova M.S. ¹

Организации

1	N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia
2	Research Institute for Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia

Toxic liver injury with the development of fi brosis and cirrhosis was modeled in Wistar rats by intragastric administration of 0.1 ml/kg CCl4 in combination with 5% ethanol with glucose 3 times a week for 6 weeks. The animals were treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It was found that betulonic acid amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, which was accompanied by a signifi cant decrease in the severity of liver fi brosis and the absence of cirrhotic transformation of the liver.

Semenov D.E. , Zhukova N.A. , Ivanova E.P. , Sorokina I.V. , Baiev D.S. , Nepomnyashchikh G.I. , Tolstikova T.G. , Biryukova M.S.
Hepatoprotective Properties of Betulonic Acid Amide and Heptral in Toxic Liver Injury Induced by Carbon Tetrachloride in Combination with Ethanol
Bulletin of Experimental Biology and Medicine. 2015. V.158. N3. P.336-341. DOI: 10.1007/s10517-015-2756-5 WOS Scopus РИНЦ

Семенов Д.Е. , Жукова Н.А. , Иванова Е.П. , Сорокина И.В. , Баев Д.С. , Непомнящих Г.И. , Толстикова Т.Г. , Борисова М.С.
Гепатопротекторные свойства амида бетулоновой кислоты и гептрала при токсическом поражении печени тетрахлорметаном в сочетании с этанолом
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2014. Т.158. №9. С.320-326. РИНЦ

Опубликована в печати:	1 янв. 2015 г.
Опубликована online:	9 янв. 2015 г.

Web of science	WOS:000348209300014
Scopus	2-s2.0-84939996122
РИНЦ	24939068
OpenAlex	W2082470462